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SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth

Renal cell carcinoma (RCC) cells have increased lipogenesis and cholesterol synthesis. Sterol regulatory element-binding protein-1 (SREBP1) is cleaved by site 1 protease (S1P) to release the transcriptionally active amino-terminal domain. PF-429242 is a potent and competitive S1P inhibitor. We here...

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Detalles Bibliográficos
Autores principales:	Wang, Tong-bing, Geng, Mei, Jin, Hua, Tang, Ai-guo, Sun, Hao, Zhou, Liu-zheng, Chen, Bin-hai, Shen, Gang, Sun, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292369/ https://www.ncbi.nlm.nih.gov/pubmed/34285190 http://dx.doi.org/10.1038/s41419-021-03999-9

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