Cargando…
Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study
OBJECTIVE: The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin in patients with knee osteoarthritis. Here, we report 5-year efficacy and safety results....
Autores principales: | Eckstein, Felix, Hochberg, Marc C, Guehring, Hans, Moreau, Flavie, Ona, Victor, Bihlet, Asger Reinstrup, Byrjalsen, Inger, Andersen, Jeppe Ragnar, Daelken, Benjamin, Guenther, Oliver, Ladel, Christoph, Michaelis, Martin, Conaghan, Philip G |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292562/ https://www.ncbi.nlm.nih.gov/pubmed/33962962 http://dx.doi.org/10.1136/annrheumdis-2020-219181 |
Ejemplares similares
-
Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial
por: Eckstein, Felix, et al.
Publicado: (2020) -
Brief Report: Intraarticular Sprifermin Not Only Increases Cartilage Thickness, but Also Reduces Cartilage Loss: Location‐Independent Post Hoc Analysis Using Magnetic Resonance Imaging
por: Eckstein, Felix, et al.
Publicado: (2015) -
Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
por: Bay-Jensen, Anne-Christine, et al.
Publicado: (2021) -
Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection
por: Ladel, C.H., et al.
Publicado: (2020) -
Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis
por: Bihlet, Asger Reinstrup, et al.
Publicado: (2018)