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Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplas...

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Autores principales: Wang, Kevin Y, Shah, Pratik, Roarke, Dennis T, Shakil, Shams A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292732/
https://www.ncbi.nlm.nih.gov/pubmed/34285024
http://dx.doi.org/10.1136/bcr-2021-242884
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author Wang, Kevin Y
Shah, Pratik
Roarke, Dennis T
Shakil, Shams A
author_facet Wang, Kevin Y
Shah, Pratik
Roarke, Dennis T
Shakil, Shams A
author_sort Wang, Kevin Y
collection PubMed
description A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.
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spelling pubmed-82927322021-08-05 Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection Wang, Kevin Y Shah, Pratik Roarke, Dennis T Shakil, Shams A BMJ Case Rep Case Report A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports. BMJ Publishing Group 2021-07-20 /pmc/articles/PMC8292732/ /pubmed/34285024 http://dx.doi.org/10.1136/bcr-2021-242884 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Wang, Kevin Y
Shah, Pratik
Roarke, Dennis T
Shakil, Shams A
Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title_full Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title_fullStr Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title_full_unstemmed Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title_short Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
title_sort severe acquired haemophilia associated with asymptomatic sars-cov-2 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292732/
https://www.ncbi.nlm.nih.gov/pubmed/34285024
http://dx.doi.org/10.1136/bcr-2021-242884
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