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GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux

T2DM (Type 2 diabetes) is a complex, chronic disease characterized as insulin resistance and islet β-cell dysfunction. Bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) surgery and laparoscopic sleeve gastrectomy (LSG) have become part of a critical treatment regimen in the treatment of ob...

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Detalles Bibliográficos
Autores principales:	Li, Rao, Sun, Xulong, Li, Pengzhou, Li, Weizheng, Zhao, Lei, Zhu, Liyong, Zhu, Shaihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292745/ https://www.ncbi.nlm.nih.gov/pubmed/34307343 http://dx.doi.org/10.3389/fcell.2021.646113

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