Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy

IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disea...

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Autores principales: Michailidou, Despina, Schwartz, Daniella Muallem, Mustelin, Tomas, Hughes, Grant C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292787/
https://www.ncbi.nlm.nih.gov/pubmed/34305927
http://dx.doi.org/10.3389/fimmu.2021.693192
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author Michailidou, Despina
Schwartz, Daniella Muallem
Mustelin, Tomas
Hughes, Grant C.
author_facet Michailidou, Despina
Schwartz, Daniella Muallem
Mustelin, Tomas
Hughes, Grant C.
author_sort Michailidou, Despina
collection PubMed
description IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia. In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines. In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential in treating patients with IgG4-RD.
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spelling pubmed-82927872021-07-22 Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy Michailidou, Despina Schwartz, Daniella Muallem Mustelin, Tomas Hughes, Grant C. Front Immunol Immunology IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia. In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines. In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential in treating patients with IgG4-RD. Frontiers Media S.A. 2021-07-07 /pmc/articles/PMC8292787/ /pubmed/34305927 http://dx.doi.org/10.3389/fimmu.2021.693192 Text en Copyright © 2021 Michailidou, Schwartz, Mustelin and Hughes https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Michailidou, Despina
Schwartz, Daniella Muallem
Mustelin, Tomas
Hughes, Grant C.
Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title_full Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title_fullStr Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title_full_unstemmed Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title_short Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy
title_sort allergic aspects of igg4-related disease: implications for pathogenesis and therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292787/
https://www.ncbi.nlm.nih.gov/pubmed/34305927
http://dx.doi.org/10.3389/fimmu.2021.693192
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