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Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor

Fish gonads develop in very diverse ways different from mammalian gonads. This diversity is contributed by species-specific factors. Gonadal somatic cell-derived factor (Gsdf) is one such factor. The gsdf gene exists mostly in teleosts and is absent in many tetrapods, probably as a result of two gen...

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Autores principales: Hsu, Chen-wei, Chung, Bon-chu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292791/
https://www.ncbi.nlm.nih.gov/pubmed/34307362
http://dx.doi.org/10.3389/fcell.2021.684352
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author Hsu, Chen-wei
Chung, Bon-chu
author_facet Hsu, Chen-wei
Chung, Bon-chu
author_sort Hsu, Chen-wei
collection PubMed
description Fish gonads develop in very diverse ways different from mammalian gonads. This diversity is contributed by species-specific factors. Gonadal somatic cell-derived factor (Gsdf) is one such factor. The gsdf gene exists mostly in teleosts and is absent in many tetrapods, probably as a result of two gene losses during evolution. The gsdf transcript is expressed mainly in gonadal somatic cells, including Sertoli cell in testis and granulosa cells in ovary; however, these gonadal somatic cells can surround many types of germ cells at different developmental stages depending on the fish species. The function of gsdf is also variable. It is involved in germ cell proliferation, testicular formation, ovarian development and even male sex determination. Here, we summarize the common and diverse expression, regulation and functions of gsdf among different fish species with aspect of evolution.
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spelling pubmed-82927912021-07-22 Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor Hsu, Chen-wei Chung, Bon-chu Front Cell Dev Biol Cell and Developmental Biology Fish gonads develop in very diverse ways different from mammalian gonads. This diversity is contributed by species-specific factors. Gonadal somatic cell-derived factor (Gsdf) is one such factor. The gsdf gene exists mostly in teleosts and is absent in many tetrapods, probably as a result of two gene losses during evolution. The gsdf transcript is expressed mainly in gonadal somatic cells, including Sertoli cell in testis and granulosa cells in ovary; however, these gonadal somatic cells can surround many types of germ cells at different developmental stages depending on the fish species. The function of gsdf is also variable. It is involved in germ cell proliferation, testicular formation, ovarian development and even male sex determination. Here, we summarize the common and diverse expression, regulation and functions of gsdf among different fish species with aspect of evolution. Frontiers Media S.A. 2021-07-07 /pmc/articles/PMC8292791/ /pubmed/34307362 http://dx.doi.org/10.3389/fcell.2021.684352 Text en Copyright © 2021 Hsu and Chung. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hsu, Chen-wei
Chung, Bon-chu
Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title_full Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title_fullStr Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title_full_unstemmed Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title_short Evolution, Expression, and Function of Gonadal Somatic Cell-Derived Factor
title_sort evolution, expression, and function of gonadal somatic cell-derived factor
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292791/
https://www.ncbi.nlm.nih.gov/pubmed/34307362
http://dx.doi.org/10.3389/fcell.2021.684352
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