Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity‐Related Properties

The trimethylation on histone H3 lysine 27 (H3k27me3), a transcriptionally repressive epigenetic mark of permissive chromatin, can be removed by the histone lysine demethylase 6a (Kdm6a). However, the physiological function of H3k27me3 and Kdm6a on circadian genes remains largely elusive. With the C...

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Detalles Bibliográficos
Autores principales: Wei, Yan, Chen, Jun, Xu, Xing, Li, Fan, Wu, Kun, Jiang, Yingying, Rao, Yuqing, Zhao, Chen, Chen, Wantao, Wang, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292908/
https://www.ncbi.nlm.nih.gov/pubmed/34306972
http://dx.doi.org/10.1002/advs.202004319

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