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Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications

Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attr...

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Detalles Bibliográficos
Autores principales: Zhang, Kaiwen, Xue, Kun, Loh, Xian Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293033/
https://www.ncbi.nlm.nih.gov/pubmed/34202514
http://dx.doi.org/10.3390/gels7030077
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author Zhang, Kaiwen
Xue, Kun
Loh, Xian Jun
author_facet Zhang, Kaiwen
Xue, Kun
Loh, Xian Jun
author_sort Zhang, Kaiwen
collection PubMed
description Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attributed to LCST behavior, micellization, and micelle aggregation of thermogelling polymers. Due to its facile phase conversion properties, thermogels are injectable yet can form an in situ gel in the human body. Thermogels act as a useful platform biomaterial that operates at physiological body temperatures. The purpose of this review is to summarize the recent progress in thermogel research, including investigations on the thermogel gelation mechanism and its applications in drug delivery, 3D cell culture, and tissue engineering. The review also discusses emerging directions in the study of thermogels.
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spelling pubmed-82930332021-07-22 Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications Zhang, Kaiwen Xue, Kun Loh, Xian Jun Gels Review Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attributed to LCST behavior, micellization, and micelle aggregation of thermogelling polymers. Due to its facile phase conversion properties, thermogels are injectable yet can form an in situ gel in the human body. Thermogels act as a useful platform biomaterial that operates at physiological body temperatures. The purpose of this review is to summarize the recent progress in thermogel research, including investigations on the thermogel gelation mechanism and its applications in drug delivery, 3D cell culture, and tissue engineering. The review also discusses emerging directions in the study of thermogels. MDPI 2021-06-24 /pmc/articles/PMC8293033/ /pubmed/34202514 http://dx.doi.org/10.3390/gels7030077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Kaiwen
Xue, Kun
Loh, Xian Jun
Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title_full Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title_fullStr Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title_full_unstemmed Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title_short Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
title_sort thermo-responsive hydrogels: from recent progress to biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293033/
https://www.ncbi.nlm.nih.gov/pubmed/34202514
http://dx.doi.org/10.3390/gels7030077
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