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Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications
Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293033/ https://www.ncbi.nlm.nih.gov/pubmed/34202514 http://dx.doi.org/10.3390/gels7030077 |
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author | Zhang, Kaiwen Xue, Kun Loh, Xian Jun |
author_facet | Zhang, Kaiwen Xue, Kun Loh, Xian Jun |
author_sort | Zhang, Kaiwen |
collection | PubMed |
description | Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attributed to LCST behavior, micellization, and micelle aggregation of thermogelling polymers. Due to its facile phase conversion properties, thermogels are injectable yet can form an in situ gel in the human body. Thermogels act as a useful platform biomaterial that operates at physiological body temperatures. The purpose of this review is to summarize the recent progress in thermogel research, including investigations on the thermogel gelation mechanism and its applications in drug delivery, 3D cell culture, and tissue engineering. The review also discusses emerging directions in the study of thermogels. |
format | Online Article Text |
id | pubmed-8293033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82930332021-07-22 Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications Zhang, Kaiwen Xue, Kun Loh, Xian Jun Gels Review Thermogels are also known as thermo-sensitive or thermo-responsive hydrogels and can undergo a sol–gel transition as the temperature increases. This thermogelling behavior is the result of combined action from multiscale thermo-responsive mechanisms. From micro to macro, these mechanisms can be attributed to LCST behavior, micellization, and micelle aggregation of thermogelling polymers. Due to its facile phase conversion properties, thermogels are injectable yet can form an in situ gel in the human body. Thermogels act as a useful platform biomaterial that operates at physiological body temperatures. The purpose of this review is to summarize the recent progress in thermogel research, including investigations on the thermogel gelation mechanism and its applications in drug delivery, 3D cell culture, and tissue engineering. The review also discusses emerging directions in the study of thermogels. MDPI 2021-06-24 /pmc/articles/PMC8293033/ /pubmed/34202514 http://dx.doi.org/10.3390/gels7030077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Kaiwen Xue, Kun Loh, Xian Jun Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title | Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title_full | Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title_fullStr | Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title_full_unstemmed | Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title_short | Thermo-Responsive Hydrogels: From Recent Progress to Biomedical Applications |
title_sort | thermo-responsive hydrogels: from recent progress to biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293033/ https://www.ncbi.nlm.nih.gov/pubmed/34202514 http://dx.doi.org/10.3390/gels7030077 |
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