Cargando…
The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer ris...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293079/ https://www.ncbi.nlm.nih.gov/pubmed/34287294 http://dx.doi.org/10.3390/curroncol28040237 |
_version_ | 1783724951858053120 |
---|---|
author | Sim, Ji-Hoon Cho, Hyun-Seok Kim, Young-Do Mun, Juhan Kim, Sung-Bae Lee, Jong-Hyuk Leem, Jeong-Gil |
author_facet | Sim, Ji-Hoon Cho, Hyun-Seok Kim, Young-Do Mun, Juhan Kim, Sung-Bae Lee, Jong-Hyuk Leem, Jeong-Gil |
author_sort | Sim, Ji-Hoon |
collection | PubMed |
description | Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Methods: Of 134,454 patients diagnosed with HZ between 2002 and 2015, 81,993 HZ patients were matched 1:1 with non-HZ individuals by age, sex, and Charlson comorbidity index. Both groups were examined at 1, 3, and 5 years for cancer diagnosis. A Cox proportional hazard regression model was used to estimate cancer risk in both groups. The postherpetic neuralgia (PHN) and non-HZ groups were compared for specific cancer risk. Results: The HZ group showed a slightly decreased overall cancer risk compared with the non-HZ group (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.97, p = 0.002). The HRs for specific cancer risk were 0.41 (95% CI, 0.33–0.50, p < 0.001); 0.86 (95% CI, 0.81–0.91, p < 0.001); 0.87 (95% CI, 0.78–0.97, p = 0.014); 0.80 (95% CI 0.73–0.87, p < 0.001); 1.20 (95% CI, 1.07–1.34, p = 0.001); and 1.66 (95% CI, 1.35–2.03, p < 0.001) for cancers of the lips, mouth, and pharynx; digestive system; respiratory system; unknown secondary and unspecified sites; thyroid and endocrine glands; and lymphoid and hematopoietic systems, respectively. The HZ with PHN group showed higher HR for specific cancer risk, such as lymphoid and hematopoietic systems (95% CI, 1.27–2.39, p < 0.001). Conclusion: HZ was associated with increased or decreased incidence of specific cancers. PHN further increased the risk of developing certain cancers in HZ patients. |
format | Online Article Text |
id | pubmed-8293079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82930792021-07-22 The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study Sim, Ji-Hoon Cho, Hyun-Seok Kim, Young-Do Mun, Juhan Kim, Sung-Bae Lee, Jong-Hyuk Leem, Jeong-Gil Curr Oncol Article Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Methods: Of 134,454 patients diagnosed with HZ between 2002 and 2015, 81,993 HZ patients were matched 1:1 with non-HZ individuals by age, sex, and Charlson comorbidity index. Both groups were examined at 1, 3, and 5 years for cancer diagnosis. A Cox proportional hazard regression model was used to estimate cancer risk in both groups. The postherpetic neuralgia (PHN) and non-HZ groups were compared for specific cancer risk. Results: The HZ group showed a slightly decreased overall cancer risk compared with the non-HZ group (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.97, p = 0.002). The HRs for specific cancer risk were 0.41 (95% CI, 0.33–0.50, p < 0.001); 0.86 (95% CI, 0.81–0.91, p < 0.001); 0.87 (95% CI, 0.78–0.97, p = 0.014); 0.80 (95% CI 0.73–0.87, p < 0.001); 1.20 (95% CI, 1.07–1.34, p = 0.001); and 1.66 (95% CI, 1.35–2.03, p < 0.001) for cancers of the lips, mouth, and pharynx; digestive system; respiratory system; unknown secondary and unspecified sites; thyroid and endocrine glands; and lymphoid and hematopoietic systems, respectively. The HZ with PHN group showed higher HR for specific cancer risk, such as lymphoid and hematopoietic systems (95% CI, 1.27–2.39, p < 0.001). Conclusion: HZ was associated with increased or decreased incidence of specific cancers. PHN further increased the risk of developing certain cancers in HZ patients. MDPI 2021-07-17 /pmc/articles/PMC8293079/ /pubmed/34287294 http://dx.doi.org/10.3390/curroncol28040237 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sim, Ji-Hoon Cho, Hyun-Seok Kim, Young-Do Mun, Juhan Kim, Sung-Bae Lee, Jong-Hyuk Leem, Jeong-Gil The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title | The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title_full | The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title_fullStr | The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title_full_unstemmed | The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title_short | The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study |
title_sort | association between herpes zoster and increased cancer risk: a nationwide population-based matched control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293079/ https://www.ncbi.nlm.nih.gov/pubmed/34287294 http://dx.doi.org/10.3390/curroncol28040237 |
work_keys_str_mv | AT simjihoon theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT chohyunseok theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT kimyoungdo theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT munjuhan theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT kimsungbae theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT leejonghyuk theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT leemjeonggil theassociationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT simjihoon associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT chohyunseok associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT kimyoungdo associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT munjuhan associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT kimsungbae associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT leejonghyuk associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy AT leemjeonggil associationbetweenherpeszosterandincreasedcancerriskanationwidepopulationbasedmatchedcontrolstudy |