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The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study

Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer ris...

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Autores principales: Sim, Ji-Hoon, Cho, Hyun-Seok, Kim, Young-Do, Mun, Juhan, Kim, Sung-Bae, Lee, Jong-Hyuk, Leem, Jeong-Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293079/
https://www.ncbi.nlm.nih.gov/pubmed/34287294
http://dx.doi.org/10.3390/curroncol28040237
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author Sim, Ji-Hoon
Cho, Hyun-Seok
Kim, Young-Do
Mun, Juhan
Kim, Sung-Bae
Lee, Jong-Hyuk
Leem, Jeong-Gil
author_facet Sim, Ji-Hoon
Cho, Hyun-Seok
Kim, Young-Do
Mun, Juhan
Kim, Sung-Bae
Lee, Jong-Hyuk
Leem, Jeong-Gil
author_sort Sim, Ji-Hoon
collection PubMed
description Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Methods: Of 134,454 patients diagnosed with HZ between 2002 and 2015, 81,993 HZ patients were matched 1:1 with non-HZ individuals by age, sex, and Charlson comorbidity index. Both groups were examined at 1, 3, and 5 years for cancer diagnosis. A Cox proportional hazard regression model was used to estimate cancer risk in both groups. The postherpetic neuralgia (PHN) and non-HZ groups were compared for specific cancer risk. Results: The HZ group showed a slightly decreased overall cancer risk compared with the non-HZ group (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.97, p = 0.002). The HRs for specific cancer risk were 0.41 (95% CI, 0.33–0.50, p < 0.001); 0.86 (95% CI, 0.81–0.91, p < 0.001); 0.87 (95% CI, 0.78–0.97, p = 0.014); 0.80 (95% CI 0.73–0.87, p < 0.001); 1.20 (95% CI, 1.07–1.34, p = 0.001); and 1.66 (95% CI, 1.35–2.03, p < 0.001) for cancers of the lips, mouth, and pharynx; digestive system; respiratory system; unknown secondary and unspecified sites; thyroid and endocrine glands; and lymphoid and hematopoietic systems, respectively. The HZ with PHN group showed higher HR for specific cancer risk, such as lymphoid and hematopoietic systems (95% CI, 1.27–2.39, p < 0.001). Conclusion: HZ was associated with increased or decreased incidence of specific cancers. PHN further increased the risk of developing certain cancers in HZ patients.
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spelling pubmed-82930792021-07-22 The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study Sim, Ji-Hoon Cho, Hyun-Seok Kim, Young-Do Mun, Juhan Kim, Sung-Bae Lee, Jong-Hyuk Leem, Jeong-Gil Curr Oncol Article Background: Herpes zoster (HZ) is strongly associated with decreased immune function, a factor of cancer development. Previous studies suggested inconsistent results regarding the association between HZ and increased cancer risk. We aimed to analyze the association between HZ and specific cancer risk. Methods: Of 134,454 patients diagnosed with HZ between 2002 and 2015, 81,993 HZ patients were matched 1:1 with non-HZ individuals by age, sex, and Charlson comorbidity index. Both groups were examined at 1, 3, and 5 years for cancer diagnosis. A Cox proportional hazard regression model was used to estimate cancer risk in both groups. The postherpetic neuralgia (PHN) and non-HZ groups were compared for specific cancer risk. Results: The HZ group showed a slightly decreased overall cancer risk compared with the non-HZ group (hazard ratio [HR] 0.94, 95% confidence interval [CI] 0.90–0.97, p = 0.002). The HRs for specific cancer risk were 0.41 (95% CI, 0.33–0.50, p < 0.001); 0.86 (95% CI, 0.81–0.91, p < 0.001); 0.87 (95% CI, 0.78–0.97, p = 0.014); 0.80 (95% CI 0.73–0.87, p < 0.001); 1.20 (95% CI, 1.07–1.34, p = 0.001); and 1.66 (95% CI, 1.35–2.03, p < 0.001) for cancers of the lips, mouth, and pharynx; digestive system; respiratory system; unknown secondary and unspecified sites; thyroid and endocrine glands; and lymphoid and hematopoietic systems, respectively. The HZ with PHN group showed higher HR for specific cancer risk, such as lymphoid and hematopoietic systems (95% CI, 1.27–2.39, p < 0.001). Conclusion: HZ was associated with increased or decreased incidence of specific cancers. PHN further increased the risk of developing certain cancers in HZ patients. MDPI 2021-07-17 /pmc/articles/PMC8293079/ /pubmed/34287294 http://dx.doi.org/10.3390/curroncol28040237 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sim, Ji-Hoon
Cho, Hyun-Seok
Kim, Young-Do
Mun, Juhan
Kim, Sung-Bae
Lee, Jong-Hyuk
Leem, Jeong-Gil
The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title_full The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title_fullStr The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title_full_unstemmed The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title_short The Association between Herpes Zoster and Increased Cancer Risk: A Nationwide Population-Based Matched Control Study
title_sort association between herpes zoster and increased cancer risk: a nationwide population-based matched control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293079/
https://www.ncbi.nlm.nih.gov/pubmed/34287294
http://dx.doi.org/10.3390/curroncol28040237
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