Cargando…
Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes?
Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293101/ https://www.ncbi.nlm.nih.gov/pubmed/34287262 http://dx.doi.org/10.3390/curroncol28040229 |
_version_ | 1783724957189013504 |
---|---|
author | Beltran-Bless, Ana-Alicia Vandermeer, Lisa Ibrahim, Mohammed F. K. Hutton, Brian Shorr, Risa Savard, Marie-France Clemons, Mark |
author_facet | Beltran-Bless, Ana-Alicia Vandermeer, Lisa Ibrahim, Mohammed F. K. Hutton, Brian Shorr, Risa Savard, Marie-France Clemons, Mark |
author_sort | Beltran-Bless, Ana-Alicia |
collection | PubMed |
description | Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or vice versa) can reduce side effects. Literature review: We conducted a literature review to evaluate whether changing the timing of tamoxifen and/or aromatase inhibitor administration impacted patient outcomes. No randomized control trials or prospective cohort studies that looked at time of day of endocrine therapy were identified through our review of literature from 1947 until August 2020. Conclusions: Given the rates of endocrine therapy non-compliance and non-persistence reported in the literature, ranging from 41–72% and 31–73%, respectively, simply changing the time of day when medications are taken could be an important strategy. We could identify no trials evaluating the effect of changes in timing of administration of endocrine therapy on breast cancer patient outcomes. Randomized control trials are clearly indicated for this simple and cost-effective intervention. |
format | Online Article Text |
id | pubmed-8293101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82931012021-07-22 Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? Beltran-Bless, Ana-Alicia Vandermeer, Lisa Ibrahim, Mohammed F. K. Hutton, Brian Shorr, Risa Savard, Marie-France Clemons, Mark Curr Oncol Opinion Background: Non-compliance and non-persistence with endocrine therapy for breast cancer is common and usually related to treatment-induced side effects. There are anecdotal reports that simply changing the time of day when taking endocrine therapy (i.e., changing morning dosing to evening dosing or vice versa) can reduce side effects. Literature review: We conducted a literature review to evaluate whether changing the timing of tamoxifen and/or aromatase inhibitor administration impacted patient outcomes. No randomized control trials or prospective cohort studies that looked at time of day of endocrine therapy were identified through our review of literature from 1947 until August 2020. Conclusions: Given the rates of endocrine therapy non-compliance and non-persistence reported in the literature, ranging from 41–72% and 31–73%, respectively, simply changing the time of day when medications are taken could be an important strategy. We could identify no trials evaluating the effect of changes in timing of administration of endocrine therapy on breast cancer patient outcomes. Randomized control trials are clearly indicated for this simple and cost-effective intervention. MDPI 2021-07-06 /pmc/articles/PMC8293101/ /pubmed/34287262 http://dx.doi.org/10.3390/curroncol28040229 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Beltran-Bless, Ana-Alicia Vandermeer, Lisa Ibrahim, Mohammed F. K. Hutton, Brian Shorr, Risa Savard, Marie-France Clemons, Mark Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title_full | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title_fullStr | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title_full_unstemmed | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title_short | Does the Time of Day at Which Endocrine Therapy Is Taken Affect Breast Cancer Patient Outcomes? |
title_sort | does the time of day at which endocrine therapy is taken affect breast cancer patient outcomes? |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293101/ https://www.ncbi.nlm.nih.gov/pubmed/34287262 http://dx.doi.org/10.3390/curroncol28040229 |
work_keys_str_mv | AT beltranblessanaalicia doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT vandermeerlisa doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT ibrahimmohammedfk doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT huttonbrian doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT shorrrisa doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT savardmariefrance doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes AT clemonsmark doesthetimeofdayatwhichendocrinetherapyistakenaffectbreastcancerpatientoutcomes |