Metal Cation Triggered Peptide Hydrogels and Their Application in Food Freshness Monitoring and Dye Adsorption

Metal-ligand interactions have emerged as an important tool to trigger and modulate self-assembly, and to tune the properties of the final supramolecular materials. Herein, we report the metal-cation induced self-assembly of a pyrene–peptide conjugate to form hydrogels. The peptide has been rationally designed to favor the formation of β-sheet 1D assemblies and metal coordination through the Glu side chains. We studied in detail the self-assembly process in the presence of H(+), Li(+), Na(+), K(+), Ca(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), Co(2+), Fe(3+), and Cr(3+) and found that the morphology and mechanical properties of the hydrogels are ion-dependent. Moreover, thanks to the presence of the metal, new applications could be explored. Cu(2+) metallogels could be used for amine sensing and meat freshness monitoring, while Zn(2+) metallogels showed good selectivity for cationic dye adsorption and separation.