Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix

Upregulation of voltage-gated sodium channels (VGSCs) and Na(+)/K(+)-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selec...

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Autores principales: Gould, Harry J., Miller, Paige R., Edenfield, Samantha, Sherman, Kelly Jean, Brady, Chad K., Paul, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293172/
https://www.ncbi.nlm.nih.gov/pubmed/34201380
http://dx.doi.org/10.3390/curroncol28030196
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author Gould, Harry J.
Miller, Paige R.
Edenfield, Samantha
Sherman, Kelly Jean
Brady, Chad K.
Paul, Dennis
author_facet Gould, Harry J.
Miller, Paige R.
Edenfield, Samantha
Sherman, Kelly Jean
Brady, Chad K.
Paul, Dennis
author_sort Gould, Harry J.
collection PubMed
description Upregulation of voltage-gated sodium channels (VGSCs) and Na(+)/K(+)-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas.
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spelling pubmed-82931722021-07-22 Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix Gould, Harry J. Miller, Paige R. Edenfield, Samantha Sherman, Kelly Jean Brady, Chad K. Paul, Dennis Curr Oncol Case Report Upregulation of voltage-gated sodium channels (VGSCs) and Na(+)/K(+)-ATPase (sodium pumps) is common across most malignant carcinomas. Targeted osmotic lysis (TOL) is a developing technology in which the concomitant stimulation of VGSCs and pharmacological blockade of sodium pumps causes rapid selective osmotic lysis of carcinoma cells. This treatment of cervical carcinoma is evidence that TOL is a safe, well-tolerated and effective treatment for aggressive advanced carcinomas that has the potential to extend life without compromising its quality. TOL is likely to have broad application for the treatment of advanced-stage carcinomas. MDPI 2021-06-08 /pmc/articles/PMC8293172/ /pubmed/34201380 http://dx.doi.org/10.3390/curroncol28030196 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Gould, Harry J.
Miller, Paige R.
Edenfield, Samantha
Sherman, Kelly Jean
Brady, Chad K.
Paul, Dennis
Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_full Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_fullStr Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_full_unstemmed Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_short Emergency Use of Targeted Osmotic Lysis for the Treatment of a Patient with Aggressive Late-Stage Squamous Cell Carcinoma of the Cervix
title_sort emergency use of targeted osmotic lysis for the treatment of a patient with aggressive late-stage squamous cell carcinoma of the cervix
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293172/
https://www.ncbi.nlm.nih.gov/pubmed/34201380
http://dx.doi.org/10.3390/curroncol28030196
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