Cargando…

A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years

Early multiple sclerosis (MS) predictive markers of disease activity/prognosis have been proposed but are not universally accepted. Aim of this pilot prospective study is to verify whether a peculiar hyperactivity, observed at baseline (T0) in early relapsing-remitting (RR) MS patients, could repres...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonetti, Lorenzo, Camilli, Federico, Giovagnoli, Sara, Natale, Vincenzo, Lugaresi, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293228/
https://www.ncbi.nlm.nih.gov/pubmed/34203507
http://dx.doi.org/10.3390/clockssleep3030023
_version_ 1783724989401268224
author Tonetti, Lorenzo
Camilli, Federico
Giovagnoli, Sara
Natale, Vincenzo
Lugaresi, Alessandra
author_facet Tonetti, Lorenzo
Camilli, Federico
Giovagnoli, Sara
Natale, Vincenzo
Lugaresi, Alessandra
author_sort Tonetti, Lorenzo
collection PubMed
description Early multiple sclerosis (MS) predictive markers of disease activity/prognosis have been proposed but are not universally accepted. Aim of this pilot prospective study is to verify whether a peculiar hyperactivity, observed at baseline (T0) in early relapsing-remitting (RR) MS patients, could represent a further prognostic marker. Here we report results collected at T0 and at a 24-month follow-up (T1). Eighteen RRMS patients (11 females, median Expanded Disability Status Scale-EDSS score 1.25, range EDSS score 0–2) were monitored at T0 (mean age 32.33 ± 7.51) and T1 (median EDSS score 1.5, range EDSS score 0–2.5). Patients were grouped into two groups: responders (R, 14 patients) and non-responders (NR, 4 patients) to treatment at T1. Each patient wore an actigraph for one week to record the 24-h motor activity pattern. At T0, NR presented significantly lower motor activity than R between around 9:00 and 13:00. At T1, NR were characterized by significantly lower motor activity than R between around 12:00 and 17:00. Overall, these data suggest that through the 24-h motor activity pattern, we can fairly segregate at T0 patients who will show a therapeutic failure, possibly related to a more active disease, at T1. These patients are characterized by a reduced morning level of motor activation. Further studies on larger populations are needed to confirm these preliminary findings.
format Online
Article
Text
id pubmed-8293228
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-82932282021-07-22 A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years Tonetti, Lorenzo Camilli, Federico Giovagnoli, Sara Natale, Vincenzo Lugaresi, Alessandra Clocks Sleep Article Early multiple sclerosis (MS) predictive markers of disease activity/prognosis have been proposed but are not universally accepted. Aim of this pilot prospective study is to verify whether a peculiar hyperactivity, observed at baseline (T0) in early relapsing-remitting (RR) MS patients, could represent a further prognostic marker. Here we report results collected at T0 and at a 24-month follow-up (T1). Eighteen RRMS patients (11 females, median Expanded Disability Status Scale-EDSS score 1.25, range EDSS score 0–2) were monitored at T0 (mean age 32.33 ± 7.51) and T1 (median EDSS score 1.5, range EDSS score 0–2.5). Patients were grouped into two groups: responders (R, 14 patients) and non-responders (NR, 4 patients) to treatment at T1. Each patient wore an actigraph for one week to record the 24-h motor activity pattern. At T0, NR presented significantly lower motor activity than R between around 9:00 and 13:00. At T1, NR were characterized by significantly lower motor activity than R between around 12:00 and 17:00. Overall, these data suggest that through the 24-h motor activity pattern, we can fairly segregate at T0 patients who will show a therapeutic failure, possibly related to a more active disease, at T1. These patients are characterized by a reduced morning level of motor activation. Further studies on larger populations are needed to confirm these preliminary findings. MDPI 2021-06-28 /pmc/articles/PMC8293228/ /pubmed/34203507 http://dx.doi.org/10.3390/clockssleep3030023 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tonetti, Lorenzo
Camilli, Federico
Giovagnoli, Sara
Natale, Vincenzo
Lugaresi, Alessandra
A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title_full A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title_fullStr A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title_full_unstemmed A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title_short A Pilot Study of 24-h Motor Activity Patterns in Multiple Sclerosis: Pre-Planned Follow-Up at 2 Years
title_sort pilot study of 24-h motor activity patterns in multiple sclerosis: pre-planned follow-up at 2 years
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293228/
https://www.ncbi.nlm.nih.gov/pubmed/34203507
http://dx.doi.org/10.3390/clockssleep3030023
work_keys_str_mv AT tonettilorenzo apilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT camillifederico apilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT giovagnolisara apilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT natalevincenzo apilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT lugaresialessandra apilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT tonettilorenzo pilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT camillifederico pilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT giovagnolisara pilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT natalevincenzo pilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years
AT lugaresialessandra pilotstudyof24hmotoractivitypatternsinmultiplesclerosispreplannedfollowupat2years