Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection

We report a case of myopericarditis associated to SARS-CoV-2 infection with necrotizing coronary vasculitis of intramural vessels, giving rise to biventricular apical microaneurysms and to electrical instability. Negativity of myocardial polymerase chain reaction for the most common cardiotropic vir...

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Autores principales: Frustaci, Andrea, Francone, Marco, Verardo, Romina, Capobianchi, Maria Rosaria, Chimenti, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293265/
https://www.ncbi.nlm.nih.gov/pubmed/34202646
http://dx.doi.org/10.3390/idr13030055
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author Frustaci, Andrea
Francone, Marco
Verardo, Romina
Capobianchi, Maria Rosaria
Chimenti, Cristina
author_facet Frustaci, Andrea
Francone, Marco
Verardo, Romina
Capobianchi, Maria Rosaria
Chimenti, Cristina
author_sort Frustaci, Andrea
collection PubMed
description We report a case of myopericarditis associated to SARS-CoV-2 infection with necrotizing coronary vasculitis of intramural vessels, giving rise to biventricular apical microaneurysms and to electrical instability. Negativity of myocardial polymerase chain reaction for the most common cardiotropic viruses and for SARS-CoV-2 suggested an immune-mediated myocardial and pericardial inflammatory disease. High dose (1 mg/Kg daily) prednisone and anti-viral (Remdesivir, IDA Business, Carrigtohill, County Cork, T45 DP77, Ireland) therapy led to resolution of cardiac inflammation and ventricular arrhythmias. Morpho-molecular characterization of endomyocardial tissue may improve the outcome in subjects with SARS-CoV-2-associated myopericarditis and coronary vasculitis.
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spelling pubmed-82932652021-07-22 Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection Frustaci, Andrea Francone, Marco Verardo, Romina Capobianchi, Maria Rosaria Chimenti, Cristina Infect Dis Rep Brief Report We report a case of myopericarditis associated to SARS-CoV-2 infection with necrotizing coronary vasculitis of intramural vessels, giving rise to biventricular apical microaneurysms and to electrical instability. Negativity of myocardial polymerase chain reaction for the most common cardiotropic viruses and for SARS-CoV-2 suggested an immune-mediated myocardial and pericardial inflammatory disease. High dose (1 mg/Kg daily) prednisone and anti-viral (Remdesivir, IDA Business, Carrigtohill, County Cork, T45 DP77, Ireland) therapy led to resolution of cardiac inflammation and ventricular arrhythmias. Morpho-molecular characterization of endomyocardial tissue may improve the outcome in subjects with SARS-CoV-2-associated myopericarditis and coronary vasculitis. MDPI 2021-06-24 /pmc/articles/PMC8293265/ /pubmed/34202646 http://dx.doi.org/10.3390/idr13030055 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Frustaci, Andrea
Francone, Marco
Verardo, Romina
Capobianchi, Maria Rosaria
Chimenti, Cristina
Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title_full Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title_fullStr Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title_full_unstemmed Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title_short Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection
title_sort virus-negative necrotizing coronary vasculitis with aneurysm formation in human sars-cov-2 infection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293265/
https://www.ncbi.nlm.nih.gov/pubmed/34202646
http://dx.doi.org/10.3390/idr13030055
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