Opportunities and Challenges for Gut Microbiota in Acute Leukemia

Acute leukemia (AL) is a highly heterogeneous hematologic malignancy, and although great progress has been made in the treatment of AL with allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and new targeted drugs, problems such as infection and GVHD in AL treatment are still serious. Ho...

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Autores principales: Ma, Tao, Chen, Yan, Li, Li-Juan, Zhang, Lian-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293295/
https://www.ncbi.nlm.nih.gov/pubmed/34307157
http://dx.doi.org/10.3389/fonc.2021.692951
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author Ma, Tao
Chen, Yan
Li, Li-Juan
Zhang, Lian-Sheng
author_facet Ma, Tao
Chen, Yan
Li, Li-Juan
Zhang, Lian-Sheng
author_sort Ma, Tao
collection PubMed
description Acute leukemia (AL) is a highly heterogeneous hematologic malignancy, and although great progress has been made in the treatment of AL with allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and new targeted drugs, problems such as infection and GVHD in AL treatment are still serious. How to reduce the incidence of AL, improve its prognosis and reduce the side effects of treatment is a crucial issue. The gut microbiota plays an important role in regulating disease progression, pathogen colonization, and immune responses. This article reviews recent advances in the gut microbiota and AL pathogenesis, infection, treatment and its role in allo-HSCT.
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spelling pubmed-82932952021-07-22 Opportunities and Challenges for Gut Microbiota in Acute Leukemia Ma, Tao Chen, Yan Li, Li-Juan Zhang, Lian-Sheng Front Oncol Oncology Acute leukemia (AL) is a highly heterogeneous hematologic malignancy, and although great progress has been made in the treatment of AL with allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and new targeted drugs, problems such as infection and GVHD in AL treatment are still serious. How to reduce the incidence of AL, improve its prognosis and reduce the side effects of treatment is a crucial issue. The gut microbiota plays an important role in regulating disease progression, pathogen colonization, and immune responses. This article reviews recent advances in the gut microbiota and AL pathogenesis, infection, treatment and its role in allo-HSCT. Frontiers Media S.A. 2021-07-07 /pmc/articles/PMC8293295/ /pubmed/34307157 http://dx.doi.org/10.3389/fonc.2021.692951 Text en Copyright © 2021 Ma, Chen, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ma, Tao
Chen, Yan
Li, Li-Juan
Zhang, Lian-Sheng
Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title_full Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title_fullStr Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title_full_unstemmed Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title_short Opportunities and Challenges for Gut Microbiota in Acute Leukemia
title_sort opportunities and challenges for gut microbiota in acute leukemia
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293295/
https://www.ncbi.nlm.nih.gov/pubmed/34307157
http://dx.doi.org/10.3389/fonc.2021.692951
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AT chenyan opportunitiesandchallengesforgutmicrobiotainacuteleukemia
AT lilijuan opportunitiesandchallengesforgutmicrobiotainacuteleukemia
AT zhangliansheng opportunitiesandchallengesforgutmicrobiotainacuteleukemia

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