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Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast

Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete productio...

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Detalles Bibliográficos
Autores principales: Andric, Vedrana, Rougemaille, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293462/
https://www.ncbi.nlm.nih.gov/pubmed/34208016
http://dx.doi.org/10.3390/ncrna7020034
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author Andric, Vedrana
Rougemaille, Mathieu
author_facet Andric, Vedrana
Rougemaille, Mathieu
author_sort Andric, Vedrana
collection PubMed
description Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis.
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spelling pubmed-82934622021-07-22 Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast Andric, Vedrana Rougemaille, Mathieu Noncoding RNA Review Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis. MDPI 2021-06-11 /pmc/articles/PMC8293462/ /pubmed/34208016 http://dx.doi.org/10.3390/ncrna7020034 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andric, Vedrana
Rougemaille, Mathieu
Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title_full Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title_fullStr Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title_full_unstemmed Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title_short Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
title_sort long non-coding rnas in the control of gametogenesis: lessons from fission yeast
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293462/
https://www.ncbi.nlm.nih.gov/pubmed/34208016
http://dx.doi.org/10.3390/ncrna7020034
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