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Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast
Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete productio...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293462/ https://www.ncbi.nlm.nih.gov/pubmed/34208016 http://dx.doi.org/10.3390/ncrna7020034 |
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author | Andric, Vedrana Rougemaille, Mathieu |
author_facet | Andric, Vedrana Rougemaille, Mathieu |
author_sort | Andric, Vedrana |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis. |
format | Online Article Text |
id | pubmed-8293462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82934622021-07-22 Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast Andric, Vedrana Rougemaille, Mathieu Noncoding RNA Review Long non-coding RNAs (lncRNAs) contribute to cell fate decisions by modulating genome expression and stability. In the fission yeast Schizosaccharomyces pombe, the transition from mitosis to meiosis results in a marked remodeling of gene expression profiles, which ultimately ensures gamete production and inheritance of genetic information to the offspring. This key developmental process involves a set of dedicated lncRNAs that shape cell cycle-dependent transcriptomes through a variety of mechanisms, including epigenetic modifications and the modulation of transcription, post-transcriptional and post-translational regulations, and that contribute to meiosis-specific chromosomal events. In this review, we summarize the biology of these lncRNAs, from their identification to mechanism of action, and discuss their regulatory role in the control of gametogenesis. MDPI 2021-06-11 /pmc/articles/PMC8293462/ /pubmed/34208016 http://dx.doi.org/10.3390/ncrna7020034 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Andric, Vedrana Rougemaille, Mathieu Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title | Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title_full | Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title_fullStr | Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title_full_unstemmed | Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title_short | Long Non-Coding RNAs in the Control of Gametogenesis: Lessons from Fission Yeast |
title_sort | long non-coding rnas in the control of gametogenesis: lessons from fission yeast |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293462/ https://www.ncbi.nlm.nih.gov/pubmed/34208016 http://dx.doi.org/10.3390/ncrna7020034 |
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