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Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children

Childhood tuberculosis (TB) is consistently under-detected in most high-burden countries, including Uganda, especially in young children at high risk for severe disease and mortality. TB preventive treatment (TPT) for high-risk child contacts is also poorly implemented. The centralised concentration...

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Autores principales: Dongo, John Paul, Graham, Stephen M., Nsonga, Joseph, Wabwire-Mangen, Fred, Maleche-Obimbo, Elizabeth, Mupere, Ezekiel, Nyinoburyo, Rodrigo, Nakawesi, Jane, Sentongo, Gerald, Amuge, Pauline, Detjen, Anne, Mugabe, Frank, Turyahabwe, Stavia, Sekadde, Moorine P., Zawedde-Muyanja, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293469/
https://www.ncbi.nlm.nih.gov/pubmed/34287383
http://dx.doi.org/10.3390/tropicalmed6030131
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author Dongo, John Paul
Graham, Stephen M.
Nsonga, Joseph
Wabwire-Mangen, Fred
Maleche-Obimbo, Elizabeth
Mupere, Ezekiel
Nyinoburyo, Rodrigo
Nakawesi, Jane
Sentongo, Gerald
Amuge, Pauline
Detjen, Anne
Mugabe, Frank
Turyahabwe, Stavia
Sekadde, Moorine P.
Zawedde-Muyanja, Stella
author_facet Dongo, John Paul
Graham, Stephen M.
Nsonga, Joseph
Wabwire-Mangen, Fred
Maleche-Obimbo, Elizabeth
Mupere, Ezekiel
Nyinoburyo, Rodrigo
Nakawesi, Jane
Sentongo, Gerald
Amuge, Pauline
Detjen, Anne
Mugabe, Frank
Turyahabwe, Stavia
Sekadde, Moorine P.
Zawedde-Muyanja, Stella
author_sort Dongo, John Paul
collection PubMed
description Childhood tuberculosis (TB) is consistently under-detected in most high-burden countries, including Uganda, especially in young children at high risk for severe disease and mortality. TB preventive treatment (TPT) for high-risk child contacts is also poorly implemented. The centralised concentration of services for child TB at the referral level is a major challenge in the prevention, detection and treatment of TB in children. In 2015, the DETECT Child TB Project was implemented in two districts of Uganda and involved decentralisation of healthcare services for child TB from tertiary to primary healthcare facilities, along with establishing linkages to support community-based household contact screening and management. The intervention resulted in improved case finding of child and adult TB cases, improved treatment outcomes for child TB and high uptake and completion of TPT for eligible child contacts. A detailed description of the development and implementation of this project is provided, along with findings from an external evaluation. The ongoing mentorship and practical support for health workers to deliver optimal services in this context were critical to complement the use of training and training tools. A summary of the project’s outcomes is provided along with the key challenges identified and the lessons learnt.
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spelling pubmed-82934692021-07-22 Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children Dongo, John Paul Graham, Stephen M. Nsonga, Joseph Wabwire-Mangen, Fred Maleche-Obimbo, Elizabeth Mupere, Ezekiel Nyinoburyo, Rodrigo Nakawesi, Jane Sentongo, Gerald Amuge, Pauline Detjen, Anne Mugabe, Frank Turyahabwe, Stavia Sekadde, Moorine P. Zawedde-Muyanja, Stella Trop Med Infect Dis Article Childhood tuberculosis (TB) is consistently under-detected in most high-burden countries, including Uganda, especially in young children at high risk for severe disease and mortality. TB preventive treatment (TPT) for high-risk child contacts is also poorly implemented. The centralised concentration of services for child TB at the referral level is a major challenge in the prevention, detection and treatment of TB in children. In 2015, the DETECT Child TB Project was implemented in two districts of Uganda and involved decentralisation of healthcare services for child TB from tertiary to primary healthcare facilities, along with establishing linkages to support community-based household contact screening and management. The intervention resulted in improved case finding of child and adult TB cases, improved treatment outcomes for child TB and high uptake and completion of TPT for eligible child contacts. A detailed description of the development and implementation of this project is provided, along with findings from an external evaluation. The ongoing mentorship and practical support for health workers to deliver optimal services in this context were critical to complement the use of training and training tools. A summary of the project’s outcomes is provided along with the key challenges identified and the lessons learnt. MDPI 2021-07-14 /pmc/articles/PMC8293469/ /pubmed/34287383 http://dx.doi.org/10.3390/tropicalmed6030131 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dongo, John Paul
Graham, Stephen M.
Nsonga, Joseph
Wabwire-Mangen, Fred
Maleche-Obimbo, Elizabeth
Mupere, Ezekiel
Nyinoburyo, Rodrigo
Nakawesi, Jane
Sentongo, Gerald
Amuge, Pauline
Detjen, Anne
Mugabe, Frank
Turyahabwe, Stavia
Sekadde, Moorine P.
Zawedde-Muyanja, Stella
Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title_full Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title_fullStr Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title_full_unstemmed Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title_short Implementation of an Effective Decentralised Programme for Detection, Treatment and Prevention of Tuberculosis in Children
title_sort implementation of an effective decentralised programme for detection, treatment and prevention of tuberculosis in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293469/
https://www.ncbi.nlm.nih.gov/pubmed/34287383
http://dx.doi.org/10.3390/tropicalmed6030131
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