Cargando…
Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and the commonest of non-communicable diseases (NCDs) in Nepal. Risk factors like indoor and outdoor air pollution, a high prevalence of smoking, and the lack of awareness of COPD make it a serio...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293490/ https://www.ncbi.nlm.nih.gov/pubmed/34289879 http://dx.doi.org/10.1186/s13063-021-05447-7 |
_version_ | 1783725049821265920 |
---|---|
author | Adhikari, Tara Ballav Neupane, Dinesh Karki, Arjun Drews, Arne Cooper, Brendan Högman, Marieann Sigsgaard, Torben Kallestrup, Per |
author_facet | Adhikari, Tara Ballav Neupane, Dinesh Karki, Arjun Drews, Arne Cooper, Brendan Högman, Marieann Sigsgaard, Torben Kallestrup, Per |
author_sort | Adhikari, Tara Ballav |
collection | PubMed |
description | BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and the commonest of non-communicable diseases (NCDs) in Nepal. Risk factors like indoor and outdoor air pollution, a high prevalence of smoking, and the lack of awareness of COPD make it a serious public health concern. However, no attempt has been made in Nepal to estimate its burden and address the disease at the community level. METHOD: This study aims to evaluate the effect of a community-based health educational intervention administered by Female Community Health Volunteers (FCHVs) on the prevention and management of COPD. An open-label, two-group, community-based, cluster-randomized controlled trial will be implemented in the semi-urban area of Pokhara Metropolitan city (former Lekhnath Municipality) located in the Kaski district of Nepal. The estimated sample size of the intervention will be 1143. The unit of randomization is the ward (administrative unit) of the study area. The follow-up survey will be conducted immediately after 12 months of FCHVs-led interventions. The difference in the rate of decline of forced expiratory volume in 1 s (FEV(1)) and FEV(1)/FVC (forced vital capacity) ratio are the primary outcomes and the change in the proportion of modifiable risk factors of COPD, health-related quality of life scores, and change in knowledge of COPD will be secondary outcomes. DISCUSSION: This study will estimate the burden of COPD, the magnitude of risk factors and generate evidence to mobilize community health workers for COPD prevention and management at the community level in Nepal. TRIAL REGISTRATION: ClinicalTrials.gov NCT03797768. Registered on January 9, 2019. |
format | Online Article Text |
id | pubmed-8293490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82934902021-07-21 Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial Adhikari, Tara Ballav Neupane, Dinesh Karki, Arjun Drews, Arne Cooper, Brendan Högman, Marieann Sigsgaard, Torben Kallestrup, Per Trials Study Protocol BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide and the commonest of non-communicable diseases (NCDs) in Nepal. Risk factors like indoor and outdoor air pollution, a high prevalence of smoking, and the lack of awareness of COPD make it a serious public health concern. However, no attempt has been made in Nepal to estimate its burden and address the disease at the community level. METHOD: This study aims to evaluate the effect of a community-based health educational intervention administered by Female Community Health Volunteers (FCHVs) on the prevention and management of COPD. An open-label, two-group, community-based, cluster-randomized controlled trial will be implemented in the semi-urban area of Pokhara Metropolitan city (former Lekhnath Municipality) located in the Kaski district of Nepal. The estimated sample size of the intervention will be 1143. The unit of randomization is the ward (administrative unit) of the study area. The follow-up survey will be conducted immediately after 12 months of FCHVs-led interventions. The difference in the rate of decline of forced expiratory volume in 1 s (FEV(1)) and FEV(1)/FVC (forced vital capacity) ratio are the primary outcomes and the change in the proportion of modifiable risk factors of COPD, health-related quality of life scores, and change in knowledge of COPD will be secondary outcomes. DISCUSSION: This study will estimate the burden of COPD, the magnitude of risk factors and generate evidence to mobilize community health workers for COPD prevention and management at the community level in Nepal. TRIAL REGISTRATION: ClinicalTrials.gov NCT03797768. Registered on January 9, 2019. BioMed Central 2021-07-21 /pmc/articles/PMC8293490/ /pubmed/34289879 http://dx.doi.org/10.1186/s13063-021-05447-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Adhikari, Tara Ballav Neupane, Dinesh Karki, Arjun Drews, Arne Cooper, Brendan Högman, Marieann Sigsgaard, Torben Kallestrup, Per Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title | Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title_full | Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title_fullStr | Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title_full_unstemmed | Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title_short | Community-based intervention for prevention and management of chronic obstructive pulmonary disease in Nepal (COBIN-P trial): study protocol for a cluster-randomized controlled trial |
title_sort | community-based intervention for prevention and management of chronic obstructive pulmonary disease in nepal (cobin-p trial): study protocol for a cluster-randomized controlled trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293490/ https://www.ncbi.nlm.nih.gov/pubmed/34289879 http://dx.doi.org/10.1186/s13063-021-05447-7 |
work_keys_str_mv | AT adhikaritaraballav communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT neupanedinesh communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT karkiarjun communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT drewsarne communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT cooperbrendan communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT hogmanmarieann communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT sigsgaardtorben communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial AT kallestrupper communitybasedinterventionforpreventionandmanagementofchronicobstructivepulmonarydiseaseinnepalcobinptrialstudyprotocolforaclusterrandomizedcontrolledtrial |