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Prognostic factors for ovarian metastases in colorectal cancer patients

PURPOSE: The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scoring system for prognosis of OM of CRC patients after surgery. PATIENTS AND METHODS:...

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Autores principales: Chen, Chao, Wang, Da, Ge, Xiaoxu, Wang, Jian, Huang, Yuhuai, Ling, Tianyi, Jin, Tian, Yang, Jinhua, Wang, Fengping, Wu, Weihong, Sun, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293531/
https://www.ncbi.nlm.nih.gov/pubmed/34284773
http://dx.doi.org/10.1186/s12957-021-02305-3
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author Chen, Chao
Wang, Da
Ge, Xiaoxu
Wang, Jian
Huang, Yuhuai
Ling, Tianyi
Jin, Tian
Yang, Jinhua
Wang, Fengping
Wu, Weihong
Sun, Lifeng
author_facet Chen, Chao
Wang, Da
Ge, Xiaoxu
Wang, Jian
Huang, Yuhuai
Ling, Tianyi
Jin, Tian
Yang, Jinhua
Wang, Fengping
Wu, Weihong
Sun, Lifeng
author_sort Chen, Chao
collection PubMed
description PURPOSE: The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scoring system for prognosis of OM of CRC patients after surgery. PATIENTS AND METHODS: Data of CRC patients with OM were collected from a single Chinese institution (n = 67). Kaplan-Meier analysis was used to evaluate cumulative survival of patients. Factors associated with prognosis of overall survival (OS) were explored using Cox’s proportional hazard regression models. A scoring system to determine effectiveness of prognosis was developed. RESULTS: Median OS values for patients with or without surgery were 22 and 7 months, respectively. Size of OM, number of OM, peritoneal metastasis (PM), Peritoneal cancer index (PCI), and completeness of cytoreduction (CC) were associated with OS of patients through univariate analysis. Multivariate analysis using a Cox regression model showed that only CC was an independent predictor for OS. Three variables (the size of OM >15cm, PCI ≥ 10, and carcinoembryonic antigen (CEA) >30 ng/mL) assigned one point each were used to develop a risk score. The resulting score was used for prognosis of OS. CONCLUSION: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis. The scoring system developed in this study is effective for prediction of OS of patients after surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-021-02305-3.
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spelling pubmed-82935312021-07-21 Prognostic factors for ovarian metastases in colorectal cancer patients Chen, Chao Wang, Da Ge, Xiaoxu Wang, Jian Huang, Yuhuai Ling, Tianyi Jin, Tian Yang, Jinhua Wang, Fengping Wu, Weihong Sun, Lifeng World J Surg Oncol Research PURPOSE: The aim of this study was to analyze prognostic factors for ovarian metastases (OM) in colorectal cancer (CRC) using data from a Chinese center. In addition, the study aimed at developing a new clinical scoring system for prognosis of OM of CRC patients after surgery. PATIENTS AND METHODS: Data of CRC patients with OM were collected from a single Chinese institution (n = 67). Kaplan-Meier analysis was used to evaluate cumulative survival of patients. Factors associated with prognosis of overall survival (OS) were explored using Cox’s proportional hazard regression models. A scoring system to determine effectiveness of prognosis was developed. RESULTS: Median OS values for patients with or without surgery were 22 and 7 months, respectively. Size of OM, number of OM, peritoneal metastasis (PM), Peritoneal cancer index (PCI), and completeness of cytoreduction (CC) were associated with OS of patients through univariate analysis. Multivariate analysis using a Cox regression model showed that only CC was an independent predictor for OS. Three variables (the size of OM >15cm, PCI ≥ 10, and carcinoembryonic antigen (CEA) >30 ng/mL) assigned one point each were used to develop a risk score. The resulting score was used for prognosis of OS. CONCLUSION: Surgical treatment of metastatic sites is effective and safe for CRC patients with OM. CC-0 is recommended for improved prognosis. The scoring system developed in this study is effective for prediction of OS of patients after surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12957-021-02305-3. BioMed Central 2021-07-20 /pmc/articles/PMC8293531/ /pubmed/34284773 http://dx.doi.org/10.1186/s12957-021-02305-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chen, Chao
Wang, Da
Ge, Xiaoxu
Wang, Jian
Huang, Yuhuai
Ling, Tianyi
Jin, Tian
Yang, Jinhua
Wang, Fengping
Wu, Weihong
Sun, Lifeng
Prognostic factors for ovarian metastases in colorectal cancer patients
title Prognostic factors for ovarian metastases in colorectal cancer patients
title_full Prognostic factors for ovarian metastases in colorectal cancer patients
title_fullStr Prognostic factors for ovarian metastases in colorectal cancer patients
title_full_unstemmed Prognostic factors for ovarian metastases in colorectal cancer patients
title_short Prognostic factors for ovarian metastases in colorectal cancer patients
title_sort prognostic factors for ovarian metastases in colorectal cancer patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293531/
https://www.ncbi.nlm.nih.gov/pubmed/34284773
http://dx.doi.org/10.1186/s12957-021-02305-3
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