Dasatinib enhances anti-leukemia efficacy of chimeric antigen receptor T cells by inhibiting cell differentiation and exhaustion

Relapses of CD19-expressing leukemia in patients who achieved initial remission after CART cell treatment have been reported to correlate with poor CART cells persistence. Sustained tonic signaling or strong activation drives CART cell differentiation and exhaustion, which limit the therapeutic effi...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Hu, Yongxian, Shao, Mi, Teng, Xinyi, Jiang, Penglei, Wang, Xiujian, Wang, Hui, Cui, Jiazhen, Yu, Jian, Liang, Zuyu, Ding, Lijuan, Han, Yingli, Wei, Jieping, Xu, Yulin, Li, Xiaoqing, Shan, Wei, Shi, Jimin, Luo, Yi, Qian, Pengxu, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293573/
https://www.ncbi.nlm.nih.gov/pubmed/34289897
http://dx.doi.org/10.1186/s13045-021-01117-y

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