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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

DNA double-strand breaks (DSBs) are repaired mainly by non-homologous end joining (NHEJ) or homologous recombination (HR). RIF1 negatively regulates resection through the effector Shieldin, which associates with a short 3′ single-stranded DNA (ssDNA) overhang by the MRN (MRE11-RAD50-NBS1) complex, t...

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Detalles Bibliográficos
Autores principales:	Isobe, Shin-Ya, Hiraga, Shin-ichiro, Nagao, Koji, Sasanuma, Hiroyuki, Donaldson, Anne D., Obuse, Chikashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293623/ https://www.ncbi.nlm.nih.gov/pubmed/34260925 http://dx.doi.org/10.1016/j.celrep.2021.109383

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