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IL-7R signaling activates widespread V(H) and D(H) gene usage to drive antibody diversity in bone marrow B cells

Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh recombination has been difficult to partition from its role in B cell survival and prolif...

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Detalles Bibliográficos
Autores principales:	Baizan-Edge, Amanda, Stubbs, Bryony A., Stubbington, Michael J.T., Bolland, Daniel J., Tabbada, Kristina, Andrews, Simon, Corcoran, Anne E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293627/ https://www.ncbi.nlm.nih.gov/pubmed/34260907 http://dx.doi.org/10.1016/j.celrep.2021.109349

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