Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

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The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable by enhanced ligand binding, lateral diffusion, clustering, or co-...

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Detalles Bibliográficos
Autores principales: Lanz, Anna-Lisa, Masi, Giulia, Porciello, Nicla, Cohnen, André, Cipria, Deborah, Prakaash, Dheeraj, Bálint, Štefan, Raggiaschi, Roberto, Galgano, Donatella, Cole, David K., Lepore, Marco, Dushek, Omer, Dustin, Michael L., Sansom, Mark S.P., Kalli, Antreas C., Acuto, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293630/
https://www.ncbi.nlm.nih.gov/pubmed/34260912
http://dx.doi.org/10.1016/j.celrep.2021.109375
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