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Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy

BACKGROUND: Cerebral amyloid angiopathy (CAA) contributes to brain neurodegeneration and cognitive decline, but the relationship between these two processes is incompletely understood. OBJECTIVE: The purpose of this study is to examine cortical thickness and its association with cognition and neurod...

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Autores principales: Subotic, Arsenije, McCreary, Cheryl R., Saad, Feryal, Nguyen, Amanda, Alvarez-Veronesi, Ana, Zwiers, Angela M., Charlton, Anna, Beaudin, Andrew E., Ismail, Zahinoor, Pike, G. Bruce, Smith, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293635/
https://www.ncbi.nlm.nih.gov/pubmed/33998545
http://dx.doi.org/10.3233/JAD-210138
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author Subotic, Arsenije
McCreary, Cheryl R.
Saad, Feryal
Nguyen, Amanda
Alvarez-Veronesi, Ana
Zwiers, Angela M.
Charlton, Anna
Beaudin, Andrew E.
Ismail, Zahinoor
Pike, G. Bruce
Smith, Eric E.
author_facet Subotic, Arsenije
McCreary, Cheryl R.
Saad, Feryal
Nguyen, Amanda
Alvarez-Veronesi, Ana
Zwiers, Angela M.
Charlton, Anna
Beaudin, Andrew E.
Ismail, Zahinoor
Pike, G. Bruce
Smith, Eric E.
author_sort Subotic, Arsenije
collection PubMed
description BACKGROUND: Cerebral amyloid angiopathy (CAA) contributes to brain neurodegeneration and cognitive decline, but the relationship between these two processes is incompletely understood. OBJECTIVE: The purpose of this study is to examine cortical thickness and its association with cognition and neurodegenerative biomarkers in CAA. METHODS: Data were collected from the Functional Assessment of Vascular Reactivity study and the Calgary Normative Study. In total, 48 participants with probable CAA, 72 cognitively normal healthy controls, and 24 participants with mild dementia due to AD were included. Participants underwent an MRI scan, after which global and regional cortical thickness measurements were obtained using FreeSurfer. General linear models, adjusted for age and sex, were used to compare cortical thickness globally and in an AD signature region. RESULTS: Global cortical thickness was lower in CAA compared to healthy controls (mean difference (MD) –0.047 mm, 95% confidence interval (CI) –0.088, –0.005, p = 0.03), and lower in AD compared to CAA (MD –0.104 mm, 95% CI –0.165, –0.043, p = 0.001). In the AD signature region, cortical thickness was lower in CAA compared to healthy controls (MD –0.07 mm, 95% CI –0.13 to –0.01, p = 0.02). Within the CAA group, lower cortical thickness was associated with lower memory scores (R(2) = 0.10; p = 0.05) and higher white matter hyperintensity volume (R(2) = 0.09, p = 0.04). CONCLUSION: CAA contributes to neurodegeneration in the form of lower cortical thickness, and this could contribute to cognitive decline. Regional overlap with an AD cortical atrophy signature region suggests that co-existing AD pathology may contribute to lower cortical thickness observed in CAA.
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spelling pubmed-82936352021-08-05 Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy Subotic, Arsenije McCreary, Cheryl R. Saad, Feryal Nguyen, Amanda Alvarez-Veronesi, Ana Zwiers, Angela M. Charlton, Anna Beaudin, Andrew E. Ismail, Zahinoor Pike, G. Bruce Smith, Eric E. J Alzheimers Dis Research Article BACKGROUND: Cerebral amyloid angiopathy (CAA) contributes to brain neurodegeneration and cognitive decline, but the relationship between these two processes is incompletely understood. OBJECTIVE: The purpose of this study is to examine cortical thickness and its association with cognition and neurodegenerative biomarkers in CAA. METHODS: Data were collected from the Functional Assessment of Vascular Reactivity study and the Calgary Normative Study. In total, 48 participants with probable CAA, 72 cognitively normal healthy controls, and 24 participants with mild dementia due to AD were included. Participants underwent an MRI scan, after which global and regional cortical thickness measurements were obtained using FreeSurfer. General linear models, adjusted for age and sex, were used to compare cortical thickness globally and in an AD signature region. RESULTS: Global cortical thickness was lower in CAA compared to healthy controls (mean difference (MD) –0.047 mm, 95% confidence interval (CI) –0.088, –0.005, p = 0.03), and lower in AD compared to CAA (MD –0.104 mm, 95% CI –0.165, –0.043, p = 0.001). In the AD signature region, cortical thickness was lower in CAA compared to healthy controls (MD –0.07 mm, 95% CI –0.13 to –0.01, p = 0.02). Within the CAA group, lower cortical thickness was associated with lower memory scores (R(2) = 0.10; p = 0.05) and higher white matter hyperintensity volume (R(2) = 0.09, p = 0.04). CONCLUSION: CAA contributes to neurodegeneration in the form of lower cortical thickness, and this could contribute to cognitive decline. Regional overlap with an AD cortical atrophy signature region suggests that co-existing AD pathology may contribute to lower cortical thickness observed in CAA. IOS Press 2021-06-15 /pmc/articles/PMC8293635/ /pubmed/33998545 http://dx.doi.org/10.3233/JAD-210138 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Subotic, Arsenije
McCreary, Cheryl R.
Saad, Feryal
Nguyen, Amanda
Alvarez-Veronesi, Ana
Zwiers, Angela M.
Charlton, Anna
Beaudin, Andrew E.
Ismail, Zahinoor
Pike, G. Bruce
Smith, Eric E.
Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title_full Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title_fullStr Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title_full_unstemmed Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title_short Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy
title_sort cortical thickness and its association with clinical cognitive and neuroimaging markers in cerebral amyloid angiopathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293635/
https://www.ncbi.nlm.nih.gov/pubmed/33998545
http://dx.doi.org/10.3233/JAD-210138
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