Cargando…

Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States

BACKGROUND: Dementia is commonly accompanied by neurobehavioral symptoms; however, the relationship between such symptoms and health-related outcomes is unclear. OBJECTIVE: To investigate the impact of specific neurobehavioral symptoms in dementia on healthcare resource use (HCRU), patient quality o...

Descripción completa

Detalles Bibliográficos
Autores principales: Chekani, Farid, Pike, James, Jones, Eddie, Husbands, Joseph, Khandker, Rezaul K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293640/
https://www.ncbi.nlm.nih.gov/pubmed/34057080
http://dx.doi.org/10.3233/JAD-201483
_version_ 1783725085053419520
author Chekani, Farid
Pike, James
Jones, Eddie
Husbands, Joseph
Khandker, Rezaul K.
author_facet Chekani, Farid
Pike, James
Jones, Eddie
Husbands, Joseph
Khandker, Rezaul K.
author_sort Chekani, Farid
collection PubMed
description BACKGROUND: Dementia is commonly accompanied by neurobehavioral symptoms; however, the relationship between such symptoms and health-related outcomes is unclear. OBJECTIVE: To investigate the impact of specific neurobehavioral symptoms in dementia on healthcare resource use (HCRU), patient quality of life (QoL), and caregiver burden. METHODS: Data were taken from the 2015/16 Adelphi Real World Dementia Disease Specific Programme™, a point-in-time survey of physicians and their consulting dementia patients. Multiple regression analyses were used to examine associations between patient symptom groups and health-related outcomes. RESULTS: Each patient symptom group of interest (patients with agitation/aggression and related symptoms [AARS] with psychosis, patients with AARS without psychosis, and patients with other behavioral symptoms) had a positive association with HCRU variables (i.e., HCRU was greater), a negative association with proxy measures of patient QoL (i.e., QoL was decreased), and a positive association with caregiver burden (i.e., burden was greater) compared with patients with no behavioral symptoms (control group). The magnitude of effect was generally greatest in patients with AARS with psychosis. Regression analysis covariates that were found to be most often significantly related to the outcomes were dementia severity and the patients’ living situation (i.e., whether they were in nursing homes or living in the community). CONCLUSION: Combinations of behavioral symptoms, particularly involving AARS plus psychosis, may have a detrimental impact on health-related outcomes such as HCRU, patient QoL, and caregiver burden in dementia. Our results have implications for intervention development in patients who report clusters of symptoms and caregivers, and for identifying at-risk individuals.
format Online
Article
Text
id pubmed-8293640
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-82936402021-08-05 Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States Chekani, Farid Pike, James Jones, Eddie Husbands, Joseph Khandker, Rezaul K. J Alzheimers Dis Research Article BACKGROUND: Dementia is commonly accompanied by neurobehavioral symptoms; however, the relationship between such symptoms and health-related outcomes is unclear. OBJECTIVE: To investigate the impact of specific neurobehavioral symptoms in dementia on healthcare resource use (HCRU), patient quality of life (QoL), and caregiver burden. METHODS: Data were taken from the 2015/16 Adelphi Real World Dementia Disease Specific Programme™, a point-in-time survey of physicians and their consulting dementia patients. Multiple regression analyses were used to examine associations between patient symptom groups and health-related outcomes. RESULTS: Each patient symptom group of interest (patients with agitation/aggression and related symptoms [AARS] with psychosis, patients with AARS without psychosis, and patients with other behavioral symptoms) had a positive association with HCRU variables (i.e., HCRU was greater), a negative association with proxy measures of patient QoL (i.e., QoL was decreased), and a positive association with caregiver burden (i.e., burden was greater) compared with patients with no behavioral symptoms (control group). The magnitude of effect was generally greatest in patients with AARS with psychosis. Regression analysis covariates that were found to be most often significantly related to the outcomes were dementia severity and the patients’ living situation (i.e., whether they were in nursing homes or living in the community). CONCLUSION: Combinations of behavioral symptoms, particularly involving AARS plus psychosis, may have a detrimental impact on health-related outcomes such as HCRU, patient QoL, and caregiver burden in dementia. Our results have implications for intervention development in patients who report clusters of symptoms and caregivers, and for identifying at-risk individuals. IOS Press 2021-06-15 /pmc/articles/PMC8293640/ /pubmed/34057080 http://dx.doi.org/10.3233/JAD-201483 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chekani, Farid
Pike, James
Jones, Eddie
Husbands, Joseph
Khandker, Rezaul K.
Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title_full Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title_fullStr Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title_full_unstemmed Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title_short Impact of Dementia-Related Behavioral Symptoms on Healthcare Resource Use and Caregiver Burden: Real-World Data from Europe and the United States
title_sort impact of dementia-related behavioral symptoms on healthcare resource use and caregiver burden: real-world data from europe and the united states
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293640/
https://www.ncbi.nlm.nih.gov/pubmed/34057080
http://dx.doi.org/10.3233/JAD-201483
work_keys_str_mv AT chekanifarid impactofdementiarelatedbehavioralsymptomsonhealthcareresourceuseandcaregiverburdenrealworlddatafromeuropeandtheunitedstates
AT pikejames impactofdementiarelatedbehavioralsymptomsonhealthcareresourceuseandcaregiverburdenrealworlddatafromeuropeandtheunitedstates
AT joneseddie impactofdementiarelatedbehavioralsymptomsonhealthcareresourceuseandcaregiverburdenrealworlddatafromeuropeandtheunitedstates
AT husbandsjoseph impactofdementiarelatedbehavioralsymptomsonhealthcareresourceuseandcaregiverburdenrealworlddatafromeuropeandtheunitedstates
AT khandkerrezaulk impactofdementiarelatedbehavioralsymptomsonhealthcareresourceuseandcaregiverburdenrealworlddatafromeuropeandtheunitedstates