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The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)

BACKGROUND: People with Down syndrome (DS) are at high risk to develop Alzheimer’s disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are lackin...

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Autores principales: Dekker, Alain D., Ulgiati, Aurora M., Groen, Henk, Boxelaar, Vincent A., Sacco, Silvia, Falquero, Ségolène, Carfi, Angelo, di Paola, Antonella, Benejam, Bessy, Valldeneu, Silvia, Fopma, Roelie, Oosterik, Marjo, Hermelink, Marloes, Beugelsdijk, Gonny, Schippers, Mieke, Henstra, Hepie, Scholten-Kuiper, Martine, Willink-Vos, Judith, de Ruiter, Lisa, Willems, Liesbeth, Loonstra-de Jong, Anneke, Coppus, Antonia M.W., Tollenaere, Marleen, Fortea, Juan, Onder, Graziano, Rebillat, Anne-Sophie, Van Dam, Debby, De Deyn, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293661/
https://www.ncbi.nlm.nih.gov/pubmed/33967040
http://dx.doi.org/10.3233/JAD-201427
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author Dekker, Alain D.
Ulgiati, Aurora M.
Groen, Henk
Boxelaar, Vincent A.
Sacco, Silvia
Falquero, Ségolène
Carfi, Angelo
di Paola, Antonella
Benejam, Bessy
Valldeneu, Silvia
Fopma, Roelie
Oosterik, Marjo
Hermelink, Marloes
Beugelsdijk, Gonny
Schippers, Mieke
Henstra, Hepie
Scholten-Kuiper, Martine
Willink-Vos, Judith
de Ruiter, Lisa
Willems, Liesbeth
Loonstra-de Jong, Anneke
Coppus, Antonia M.W.
Tollenaere, Marleen
Fortea, Juan
Onder, Graziano
Rebillat, Anne-Sophie
Van Dam, Debby
De Deyn, Peter P.
author_facet Dekker, Alain D.
Ulgiati, Aurora M.
Groen, Henk
Boxelaar, Vincent A.
Sacco, Silvia
Falquero, Ségolène
Carfi, Angelo
di Paola, Antonella
Benejam, Bessy
Valldeneu, Silvia
Fopma, Roelie
Oosterik, Marjo
Hermelink, Marloes
Beugelsdijk, Gonny
Schippers, Mieke
Henstra, Hepie
Scholten-Kuiper, Martine
Willink-Vos, Judith
de Ruiter, Lisa
Willems, Liesbeth
Loonstra-de Jong, Anneke
Coppus, Antonia M.W.
Tollenaere, Marleen
Fortea, Juan
Onder, Graziano
Rebillat, Anne-Sophie
Van Dam, Debby
De Deyn, Peter P.
author_sort Dekker, Alain D.
collection PubMed
description BACKGROUND: People with Down syndrome (DS) are at high risk to develop Alzheimer’s disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are lacking. Therefore, we previously developed the BPSD-DS scale to identify behavioral changes between the last six months and pre-existing life-long characteristic behavior. OBJECTIVE: To optimize and further study the scale (discriminative ability and reliability) in a large representative DS study population. METHODS: Optimization was based on item irrelevance and clinical experiences obtained in the initial study. Using the shortened and refined BPSD-DS II, informant interviews were conducted to evaluate 524 individuals with DS grouped according to dementia status: no dementia (DS, N = 292), questionable dementia (DS + Q, N = 119), and clinically diagnosed dementia (DS + AD, N = 113). RESULTS: Comparing item change scores between groups revealed prominent changes in frequency and severity for anxious, sleep-related, irritable, restless/stereotypic, apathetic, depressive, and eating/drinking behavior. For most items, the proportion of individuals displaying an increased frequency was highest in DS + AD, intermediate in DS + Q, and lowest in DS. For various items within sections about anxious, sleep-related, irritable, apathetic, and depressive behaviors, the proportion of individuals showing an increased frequency was already substantial in DS + Q, suggesting that these changes may serve as early signals of AD in DS. Reliability data were promising. CONCLUSION: The optimized scale yields largely similar results as obtained with the initial version. Systematically evaluating BPSD in DS may increase understanding of changes among caregivers and (timely) adaptation of care/treatment.
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spelling pubmed-82936612021-08-05 The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1) Dekker, Alain D. Ulgiati, Aurora M. Groen, Henk Boxelaar, Vincent A. Sacco, Silvia Falquero, Ségolène Carfi, Angelo di Paola, Antonella Benejam, Bessy Valldeneu, Silvia Fopma, Roelie Oosterik, Marjo Hermelink, Marloes Beugelsdijk, Gonny Schippers, Mieke Henstra, Hepie Scholten-Kuiper, Martine Willink-Vos, Judith de Ruiter, Lisa Willems, Liesbeth Loonstra-de Jong, Anneke Coppus, Antonia M.W. Tollenaere, Marleen Fortea, Juan Onder, Graziano Rebillat, Anne-Sophie Van Dam, Debby De Deyn, Peter P. J Alzheimers Dis Research Article BACKGROUND: People with Down syndrome (DS) are at high risk to develop Alzheimer’s disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are lacking. Therefore, we previously developed the BPSD-DS scale to identify behavioral changes between the last six months and pre-existing life-long characteristic behavior. OBJECTIVE: To optimize and further study the scale (discriminative ability and reliability) in a large representative DS study population. METHODS: Optimization was based on item irrelevance and clinical experiences obtained in the initial study. Using the shortened and refined BPSD-DS II, informant interviews were conducted to evaluate 524 individuals with DS grouped according to dementia status: no dementia (DS, N = 292), questionable dementia (DS + Q, N = 119), and clinically diagnosed dementia (DS + AD, N = 113). RESULTS: Comparing item change scores between groups revealed prominent changes in frequency and severity for anxious, sleep-related, irritable, restless/stereotypic, apathetic, depressive, and eating/drinking behavior. For most items, the proportion of individuals displaying an increased frequency was highest in DS + AD, intermediate in DS + Q, and lowest in DS. For various items within sections about anxious, sleep-related, irritable, apathetic, and depressive behaviors, the proportion of individuals showing an increased frequency was already substantial in DS + Q, suggesting that these changes may serve as early signals of AD in DS. Reliability data were promising. CONCLUSION: The optimized scale yields largely similar results as obtained with the initial version. Systematically evaluating BPSD in DS may increase understanding of changes among caregivers and (timely) adaptation of care/treatment. IOS Press 2021-06-15 /pmc/articles/PMC8293661/ /pubmed/33967040 http://dx.doi.org/10.3233/JAD-201427 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dekker, Alain D.
Ulgiati, Aurora M.
Groen, Henk
Boxelaar, Vincent A.
Sacco, Silvia
Falquero, Ségolène
Carfi, Angelo
di Paola, Antonella
Benejam, Bessy
Valldeneu, Silvia
Fopma, Roelie
Oosterik, Marjo
Hermelink, Marloes
Beugelsdijk, Gonny
Schippers, Mieke
Henstra, Hepie
Scholten-Kuiper, Martine
Willink-Vos, Judith
de Ruiter, Lisa
Willems, Liesbeth
Loonstra-de Jong, Anneke
Coppus, Antonia M.W.
Tollenaere, Marleen
Fortea, Juan
Onder, Graziano
Rebillat, Anne-Sophie
Van Dam, Debby
De Deyn, Peter P.
The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title_full The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title_fullStr The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title_full_unstemmed The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title_short The Behavioral and Psychological Symptoms of Dementia in Down Syndrome Scale (BPSD-DS II): Optimization and Further Validation(1)
title_sort behavioral and psychological symptoms of dementia in down syndrome scale (bpsd-ds ii): optimization and further validation(1)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293661/
https://www.ncbi.nlm.nih.gov/pubmed/33967040
http://dx.doi.org/10.3233/JAD-201427
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