The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and it...

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Detalles Bibliográficos
Autores principales: Zheng, Xiangtao, Chen, Weiwei, Gong, Fangchen, Chen, Ying, Chen, Erzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293747/
https://www.ncbi.nlm.nih.gov/pubmed/34305952
http://dx.doi.org/10.3389/fimmu.2021.711939
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author Zheng, Xiangtao
Chen, Weiwei
Gong, Fangchen
Chen, Ying
Chen, Erzhen
author_facet Zheng, Xiangtao
Chen, Weiwei
Gong, Fangchen
Chen, Ying
Chen, Erzhen
author_sort Zheng, Xiangtao
collection PubMed
description Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and its relationship with sepsis, including the mechanisms, role, and relevant targets of pyroptosis in sepsis. While moderate pyroptosis in sepsis can control pathogen infection, excessive pyroptosis can lead to a dysregulated host immune response and even organ dysfunction. This review provides an overview of the mechanisms and potential therapeutic targets underlying pyroptosis in sepsis identified in recent decades, looking forward to the future direction of treatment for sepsis.
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spelling pubmed-82937472021-07-22 The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review Zheng, Xiangtao Chen, Weiwei Gong, Fangchen Chen, Ying Chen, Erzhen Front Immunol Immunology Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Recently was been found that pyroptosis is a unique form of proinflammatory programmed death, that is different from apoptosis. A growing number of studies have investigated pyroptosis and its relationship with sepsis, including the mechanisms, role, and relevant targets of pyroptosis in sepsis. While moderate pyroptosis in sepsis can control pathogen infection, excessive pyroptosis can lead to a dysregulated host immune response and even organ dysfunction. This review provides an overview of the mechanisms and potential therapeutic targets underlying pyroptosis in sepsis identified in recent decades, looking forward to the future direction of treatment for sepsis. Frontiers Media S.A. 2021-07-07 /pmc/articles/PMC8293747/ /pubmed/34305952 http://dx.doi.org/10.3389/fimmu.2021.711939 Text en Copyright © 2021 Zheng, Chen, Gong, Chen and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Xiangtao
Chen, Weiwei
Gong, Fangchen
Chen, Ying
Chen, Erzhen
The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title_full The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title_fullStr The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title_full_unstemmed The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title_short The Role and Mechanism of Pyroptosis and Potential Therapeutic Targets in Sepsis: A Review
title_sort role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293747/
https://www.ncbi.nlm.nih.gov/pubmed/34305952
http://dx.doi.org/10.3389/fimmu.2021.711939
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