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Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL

In this manuscript, we developed a two-fold symmetric linchpin (TSL) that converts readily available phage-displayed peptides libraries made of 20 common amino acids to genetically-encoded libraries of bicyclic peptides displayed on phage. TSL combines an aldehyde-reactive group and two thiol-reacti...

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Detalles Bibliográficos
Autores principales:	Wong, Jeffrey Y.-K., Mukherjee, Raja, Miao, Jiayuan, Bilyk, Olena, Triana, Vivian, Miskolzie, Mark, Henninot, Antoine, Dwyer, John J., Kharchenko, Serhii, Iampolska, Anna, Volochnyuk, Dmitriy M., Lin, Yu-Shan, Postovit, Lynne-Marie, Derda, Ratmir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294009/ https://www.ncbi.nlm.nih.gov/pubmed/34349940 http://dx.doi.org/10.1039/d1sc01916c

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