Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy

Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by...

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Autores principales: Li, Si, Sharma, Nishant, Kazmierski, Daniel, Amjad, Mohammad Asim, Dong, Yishan, Wang, Yichen, Sharma, Namita, Ramakrishna, Srinivasarao, Ochieng, Pius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294017/
https://www.ncbi.nlm.nih.gov/pubmed/34306873
http://dx.doi.org/10.7759/cureus.15805
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author Li, Si
Sharma, Nishant
Kazmierski, Daniel
Amjad, Mohammad Asim
Dong, Yishan
Wang, Yichen
Sharma, Namita
Ramakrishna, Srinivasarao
Ochieng, Pius
author_facet Li, Si
Sharma, Nishant
Kazmierski, Daniel
Amjad, Mohammad Asim
Dong, Yishan
Wang, Yichen
Sharma, Namita
Ramakrishna, Srinivasarao
Ochieng, Pius
author_sort Li, Si
collection PubMed
description Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by the COVID-19 pandemic. We report a case of a patient with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage (DAH) following treatment with avelumab.
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spelling pubmed-82940172021-07-23 Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy Li, Si Sharma, Nishant Kazmierski, Daniel Amjad, Mohammad Asim Dong, Yishan Wang, Yichen Sharma, Namita Ramakrishna, Srinivasarao Ochieng, Pius Cureus Internal Medicine Immune checkpoint blockade is a rapidly expanding therapeutic modality in oncology. However, its adverse effects extend beyond the cytotoxicity of conventional chemotherapy. Pneumotoxicity associated with immune checkpoint therapy presents a diagnostic conundrum that has been further complicated by the COVID-19 pandemic. We report a case of a patient with metastatic urothelial carcinoma who developed diffuse alveolar hemorrhage (DAH) following treatment with avelumab. Cureus 2021-06-21 /pmc/articles/PMC8294017/ /pubmed/34306873 http://dx.doi.org/10.7759/cureus.15805 Text en Copyright © 2021, Li et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Li, Si
Sharma, Nishant
Kazmierski, Daniel
Amjad, Mohammad Asim
Dong, Yishan
Wang, Yichen
Sharma, Namita
Ramakrishna, Srinivasarao
Ochieng, Pius
Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title_full Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title_fullStr Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title_full_unstemmed Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title_short Diffuse Alveolar Hemorrhage With Avelumab Maintenance Therapy
title_sort diffuse alveolar hemorrhage with avelumab maintenance therapy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294017/
https://www.ncbi.nlm.nih.gov/pubmed/34306873
http://dx.doi.org/10.7759/cureus.15805
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