Akathisia as an Extrapyramidal Side Effect of Fluoxetine

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that is commonly prescribed for major depressive disorder (MDD). Akathisia is one of the well-recognized extrapyramidal symptoms (EPS) of antipsychotics and antiemetics, but also a rare manifestation of antidepressants. There are various documentations of EPS of antidepressants including acute dystonia, Parkinsonism, and tardive dyskinesia. Akathisia is not only a rare extrapyramidal manifestation of fluoxetine but a frequently unrecognized phenomenon in those using this medication. This case report describes a case of akathisia observed in a 69-year-old Caucasian female using fluoxetine. Various factors that may have contributed to the development of akathisia in this patient were also discussed as well as implications for clinical practice and future research.