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SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center

Since the onset of the COVID-19 pandemic, it has been unclear how vulnerable people with HIV (PwH) are to SARS-CoV-2 infection. We sought to determine if PwH are more likely to test positive for SARS-CoV-2 than people without HIV, and to identify risk factors associated with SARS-CoV-2 positivity am...

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Autores principales: Friedman, Eleanor E., Devlin, Samantha A., McNulty, Moira C., Ridgway, Jessica P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294486/
https://www.ncbi.nlm.nih.gov/pubmed/34288954
http://dx.doi.org/10.1371/journal.pone.0254994
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author Friedman, Eleanor E.
Devlin, Samantha A.
McNulty, Moira C.
Ridgway, Jessica P.
author_facet Friedman, Eleanor E.
Devlin, Samantha A.
McNulty, Moira C.
Ridgway, Jessica P.
author_sort Friedman, Eleanor E.
collection PubMed
description Since the onset of the COVID-19 pandemic, it has been unclear how vulnerable people with HIV (PwH) are to SARS-CoV-2 infection. We sought to determine if PwH are more likely to test positive for SARS-CoV-2 than people without HIV, and to identify risk factors associated with SARS-CoV-2 positivity among PwH. We conducted a cross-sectional study in which we collected electronic medical record data for all patients who underwent SARS-CoV-2 PCR testing at an academic medical center. Presence of HIV and other chronic diseases were based on the presence of ICD-10 diagnosis codes. We calculated the percent positivity for SARS-CoV-2 among PwH and among people without HIV. Among PwH, we compared demographic factors, comorbidities, HIV viral load, CD4 T-cell count, and antiretroviral therapy (ART) regimens between those who tested positive for SARS-CoV-2 and those who tested negative. Comparisons were made using chi squared tests or Wilcoxon rank sum tests. Multivariate models were created using logistic regression. Among 69,763 people tested for SARS-CoV-2, 0.6% (431) were PwH. PwH were not significantly more likely to test positive for SARS-CoV-2 than people without HIV (7.2% (31/431) vs 8.4% (5820/69763), p = 0.35), but were more likely to be younger, Black, and male (p-values < .0001). There were no significant differences in HIV clinical factors, chronic diseases, or ART regimens among PwH testing positive for SARS-CoV-2 versus those testing negative. In our sample, PwH were not more likely to contract SARS-CoV-2, despite being more likely to be members of demographic groups known to be at higher risk for infection. Differences between PwH who tested positive for SARS-CoV-2 and those who tested negative were only seen in Hispanic/Latino ethnicity (non-Hispanic or Latino vs unknown Hispanic or Latino ethnicity (OR 0.2 95% CI (0.6, 0.9)) and site of testing(inpatient vs outpatient OR 3.1 95% CI (1.3, 7.4)).
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spelling pubmed-82944862021-07-31 SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center Friedman, Eleanor E. Devlin, Samantha A. McNulty, Moira C. Ridgway, Jessica P. PLoS One Research Article Since the onset of the COVID-19 pandemic, it has been unclear how vulnerable people with HIV (PwH) are to SARS-CoV-2 infection. We sought to determine if PwH are more likely to test positive for SARS-CoV-2 than people without HIV, and to identify risk factors associated with SARS-CoV-2 positivity among PwH. We conducted a cross-sectional study in which we collected electronic medical record data for all patients who underwent SARS-CoV-2 PCR testing at an academic medical center. Presence of HIV and other chronic diseases were based on the presence of ICD-10 diagnosis codes. We calculated the percent positivity for SARS-CoV-2 among PwH and among people without HIV. Among PwH, we compared demographic factors, comorbidities, HIV viral load, CD4 T-cell count, and antiretroviral therapy (ART) regimens between those who tested positive for SARS-CoV-2 and those who tested negative. Comparisons were made using chi squared tests or Wilcoxon rank sum tests. Multivariate models were created using logistic regression. Among 69,763 people tested for SARS-CoV-2, 0.6% (431) were PwH. PwH were not significantly more likely to test positive for SARS-CoV-2 than people without HIV (7.2% (31/431) vs 8.4% (5820/69763), p = 0.35), but were more likely to be younger, Black, and male (p-values < .0001). There were no significant differences in HIV clinical factors, chronic diseases, or ART regimens among PwH testing positive for SARS-CoV-2 versus those testing negative. In our sample, PwH were not more likely to contract SARS-CoV-2, despite being more likely to be members of demographic groups known to be at higher risk for infection. Differences between PwH who tested positive for SARS-CoV-2 and those who tested negative were only seen in Hispanic/Latino ethnicity (non-Hispanic or Latino vs unknown Hispanic or Latino ethnicity (OR 0.2 95% CI (0.6, 0.9)) and site of testing(inpatient vs outpatient OR 3.1 95% CI (1.3, 7.4)). Public Library of Science 2021-07-21 /pmc/articles/PMC8294486/ /pubmed/34288954 http://dx.doi.org/10.1371/journal.pone.0254994 Text en © 2021 Friedman et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Friedman, Eleanor E.
Devlin, Samantha A.
McNulty, Moira C.
Ridgway, Jessica P.
SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title_full SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title_fullStr SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title_full_unstemmed SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title_short SARS-CoV-2 percent positivity and risk factors among people with HIV at an urban academic medical center
title_sort sars-cov-2 percent positivity and risk factors among people with hiv at an urban academic medical center
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294486/
https://www.ncbi.nlm.nih.gov/pubmed/34288954
http://dx.doi.org/10.1371/journal.pone.0254994
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