A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cells

c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc–MAX heterodimer regulates the expression of several genes, leading to an oncogeni...

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Detalles Bibliográficos
Autores principales: Singh, Ashutosh, Kumar, Ankur, Kumar, Prateek, Nayak, Namyashree, Bhardwaj, Taniya, Giri, Rajanish, Garg, Neha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294579/
https://www.ncbi.nlm.nih.gov/pubmed/34157284
http://dx.doi.org/10.1016/j.jbc.2021.100903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294579/
https://www.ncbi.nlm.nih.gov/pubmed/34157284
http://dx.doi.org/10.1016/j.jbc.2021.100903

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