Cargando…

A novel inhibitor L755507 efficiently blocks c-Myc–MAX heterodimerization and induces apoptosis in cancer cells

c-Myc is a transcription factor that plays a crucial role in cellular homeostasis, and its deregulation is associated with highly aggressive and chemotherapy-resistant cancers. After binding with partner MAX, the c-Myc–MAX heterodimer regulates the expression of several genes, leading to an oncogeni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Ashutosh, Kumar, Ankur, Kumar, Prateek, Nayak, Namyashree, Bhardwaj, Taniya, Giri, Rajanish, Garg, Neha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294579/ https://www.ncbi.nlm.nih.gov/pubmed/34157284 http://dx.doi.org/10.1016/j.jbc.2021.100903

Ejemplares similares

Functional inhibition of c-Myc using novel inhibitors identified through “hot spot” targeting
por: Singh, Ashutosh, et al.
Publicado: (2022)

Conformational dynamics of 13 amino acids long NSP11 of SARS-CoV-2 under membrane mimetics and different solvent conditions
por: Gadhave, Kundlik, et al.
Publicado: (2021)

Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242–1273) in isolation
por: Kumar, Prateek, et al.
Publicado: (2022)

Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes
por: Bhardwaj, Taniya, et al.
Publicado: (2023)

Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal
por: Kumar, Prateek, et al.
Publicado: (2022)

SARS-CoV-2 NSP1 C-terminal (residues 131–180) is an intrinsically disordered region in isolation
por: Kumar, Amit, et al.
Publicado: (2021)

MYC–MAX heterodimerization is essential for the induction of major zygotic genome activation and subsequent preimplantation development
por: Yamamoto, Takuto, et al.
Publicado: (2023)

Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability
por: Yao, Ruosi, et al.
Publicado: (2022)

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5
por: Wang, Huabo, et al.
Publicado: (2013)

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells
por: Wang, Jiandong, et al.
Publicado: (2014)

Erratum: Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5
por: Wang, Huabo, et al.
Publicado: (2018)

Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
por: Giri, Rajanish, et al.
Publicado: (2020)

Therapeutic Interventions of Cancers Using Intrinsically Disordered Proteins as Drug Targets: c-Myc as Model System
por: Kumar, Deepak, et al.
Publicado: (2017)

Targeting the nsp2 Cysteine Protease of Chikungunya Virus Using FDA Approved Library and Selected Cysteine Protease Inhibitors
por: Kumar, Prateek, et al.
Publicado: (2019)

Hydroxychloroquine Inhibits Zika Virus NS2B-NS3 Protease
por: Kumar, Ankur, et al.
Publicado: (2018)

Understanding the penetrance of intrinsic protein disorder in rotavirus proteome
por: Kumar, Deepak, et al.
Publicado: (2020)

Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91–112 & 231–290 regions
por: Kumar, Amit, et al.
Publicado: (2021)

Substituent-Controlled Structural, Supramolecular, and Cytotoxic Properties of a Series of 2-Styryl-8-nitro and 2-Styryl-8-hydroxy Quinolines
por: Sehlangia, Suman, et al.
Publicado: (2022)

Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation
por: Sharma, Nitin, et al.
Publicado: (2022)

Understanding the interactability of chikungunya virus proteins via molecular recognition feature analysis
por: Singh, Ankur, et al.
Publicado: (2018)

Deciphering the dark proteome of Chikungunya virus
por: Singh, Ankur, et al.
Publicado: (2018)

Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas
Publicado: (1994)

Drugs to limit Zika virus infection and implication for maternal-fetal health
por: Kumar, Ankur, et al.
Publicado: (2022)

Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis
por: Mathsyaraja, Haritha, et al.
Publicado: (2019)

Unstructured Biology of Proteins from Ubiquitin-Proteasome System: Roles in Cancer and Neurodegenerative Diseases
por: Gadhave, Kundlik, et al.
Publicado: (2020)

Mnt–Max to Myc–Max complex switching regulates cell cycle entry
por: Walker, William, et al.
Publicado: (2005)

Quantitative Supramolecular Heterodimerization for Efficient Energy Transfer
por: Wu, Guanglu, et al.
Publicado: (2020)

MYC-Associated Factor MAX is a Regulator of the Circadian Clock
por: Blaževitš, Olga, et al.
Publicado: (2020)

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation
por: Castell, Alina, et al.
Publicado: (2018)

Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors
por: Somvanshi, Rishi K., et al.
Publicado: (2012)

MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
por: Castell, Alina, et al.
Publicado: (2022)

Oesophageal adenocarcinoma is associated with a deregulation in the MYC/MAX/MAD network
por: Boult, J K R, et al.
Publicado: (2008)

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential
por: Raffeiner, Philipp, et al.
Publicado: (2014)

Heterodimeric Plasmonic Nanogaps for Biosensing
por: Chatterjee, Sharmistha, et al.
Publicado: (2018)

A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression
por: Holmes, Austin G., et al.
Publicado: (2022)

Efficient biosynthesis of heterodimeric C(3)-aryl pyrroloindoline alkaloids
por: Tian, Wenya, et al.
Publicado: (2018)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
por: Wang, Huabo, et al.
Publicado: (2015)

Intrinsically Disordered Side of the Zika Virus Proteome
por: Giri, Rajanish, et al.
Publicado: (2016)

Analysis of the dark proteome of Chandipura virus reveals maximum propensity for intrinsic disorder in phosphoprotein
por: Sharma, Nishi R., et al.
Publicado: (2021)

Mechanistic Insights into Zika Virus NS3 Helicase Inhibition by Epigallocatechin-3-Gallate
por: Kumar, Deepak, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_k7njeclhpruuc3kf8sglp44300