Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap

Angiopoietins Ang1 and Ang2 are secreted ligands for the endothelial receptor tyrosine kinase Tie2 essential for vascular development and maintenance. Ang1 acts as an agonist to maintain normal vessel function, whereas Ang2 acts as a Tie2 antagonist. Ang2 is increased in macular edema, sepsis, and o...

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Detalles Bibliográficos
Autores principales: Bate, Neil, Lodge, James, Brindle, Nicholas P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294587/
https://www.ncbi.nlm.nih.gov/pubmed/34153320
http://dx.doi.org/10.1016/j.jbc.2021.100888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294587/
https://www.ncbi.nlm.nih.gov/pubmed/34153320
http://dx.doi.org/10.1016/j.jbc.2021.100888

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