Cargando…

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

The dedicator of cytokinesis (DOCK) family of guanine nucleotide exchange factors (GEFs) promotes cell motility, phagocytosis, and cancer metastasis through activation of Rho guanosine triphosphatases. Engulfment and cell motility (ELMO) proteins are binding partners of DOCK and regulate Rac activat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Kaushik, Rahul, Ehara, Haruhiko, Yokoyama, Takeshi, Uchikubo-Kamo, Tomomi, Nakagawa, Reiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Ikeda, Mariko, Hanada, Kazuharu, Zhang, Kam Y. J., Shirouzu, Mikako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294757/ https://www.ncbi.nlm.nih.gov/pubmed/34290093 http://dx.doi.org/10.1126/sciadv.abg3147

Ejemplares similares

Targeting Ras-binding domain of ELMO1 by computational nanobody design
por: Tam, Chunlai, et al.
Publicado: (2023)

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
por: Shimizu, Kanako, et al.
Publicado: (2019)

Reduced efficacy of a Src kinase inhibitor in crowded protein solution
por: Kasahara, Kento, et al.
Publicado: (2021)

Structural Insight into TNIK Inhibition
por: Kukimoto-Niino, Mutsuko, et al.
Publicado: (2022)

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody–antigen interaction
por: Matsuda, Takayoshi, et al.
Publicado: (2018)

Elucidation of binding preferences of YEATS domains to site-specific acetylated nucleosome core particles
por: Kikuchi, Masaki, et al.
Publicado: (2022)

Lewis fucose is a key moiety for the recognition of histo‐blood group antigens by GI.9 norovirus, as revealed by structural analysis
por: Kimura‐Someya, Tomomi, et al.
Publicado: (2022)

Crystal Structure of an Archaeal Tyrosyl-tRNA Synthetase Bound to Photocaged L-Tyrosine and Its Potential Application to Time-Resolved X-ray Crystallography
por: Hosaka, Toshiaki, et al.
Publicado: (2022)

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration
por: Terasawa, Masao, et al.
Publicado: (2012)

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib
por: Ohbayashi, Naomi, et al.
Publicado: (2018)

Cell-permeable Carboxyl-terminal p27(Kip1) Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase
por: Morishita, Daisuke, et al.
Publicado: (2011)

A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8
por: Sakurai, Tetsuya, et al.
Publicado: (2021)

Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation
por: Shoji, Shisako, et al.
Publicado: (2017)

Epigenetic mechanisms to propagate histone acetylation by p300/CBP
por: Kikuchi, Masaki, et al.
Publicado: (2023)

Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 ( −/− ), elmo2 ( −/− ), and elmo3 ( −/− ) Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins
por: Boger, Mike, et al.
Publicado: (2022)

TNIK inhibition abrogates colorectal cancer stemness
por: Masuda, Mari, et al.
Publicado: (2016)

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs
por: Shigematsu, Hideki, et al.
Publicado: (2018)

Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope
por: Makabe, Koki, et al.
Publicado: (2021)

A shortcut from GPCR signaling to Rac-mediated actin cytoskeleton through an ELMO/DOCK complex
por: Xu, Xuehua, et al.
Publicado: (2012)

HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis
por: Janardhan, Ajit, et al.
Publicado: (2004)

Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation
por: Makino, Yoshinori, et al.
Publicado: (2015)

ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis
por: Wang, Youhong, et al.
Publicado: (2016)

Biallelic ELMO3 mutations and loss of function for DOCK-mediated RAC1 activation result in intellectual disability
por: Tran, Viviane, et al.
Publicado: (2021)

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells
por: Terasawa, Kazue, et al.
Publicado: (2021)

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis
por: Li, Hongyan, et al.
Publicado: (2013)

NSCLC metastasis: going with ELMO3
por: Goyette, Marie-Anne, et al.
Publicado: (2014)

ELMO: an innovative interface for noninvasive ventilation
por: Pinheiro, Bruno Valle, et al.
Publicado: (2022)

Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
por: Weng, Zhuangfeng, et al.
Publicado: (2019)

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches
por: Sato, Tomohiro, et al.
Publicado: (2020)

pELMO, an optimised in-house cloning vector
por: Ramos, Andrea E., et al.
Publicado: (2017)

Golgi ELMO1 binds QUA1, QUA2, GAUT9, and ELMO4 and is required for pectin accumulation in Arabidopsis
por: Kohorn, Bruce D., et al.
Publicado: (2023)

Cell-Free Protein Synthesis Using S30 Extracts from Escherichia coli RFzero Strains for Efficient Incorporation of Non-Natural Amino Acids into Proteins
por: Adachi, Jiro, et al.
Publicado: (2019)

Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple-negative breast cancer epithelial cells through the RhoA/Rac1 pathway
por: Liang, Yueyang, et al.
Publicado: (2018)

De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones
por: McCauley, Heather A, et al.
Publicado: (2017)

Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY(®) compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation
por: Kyuuma, Masanao, et al.
Publicado: (2023)

ELMO1: More Than Just a Director of Phagocytosis
por: McCormick, Beth A.
Publicado: (2015)

Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1
por: Kim, Kwanhyeong, et al.
Publicado: (2017)

ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis
por: Yu, Shuxiang, et al.
Publicado: (2023)

Cryo-EM structure of the photosynthetic RC-LH1-PufX supercomplex at 2.8-Å resolution
por: Bracun, Laura, et al.
Publicado: (2021)

Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents
por: Takeshita, Masaru, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tlits5u36ur26uh6m100u7lvsr