Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo

Variants in FTO have the strongest association with obesity; however, it is still unclear how those noncoding variants mechanistically affect whole-body physiology. We engineered a deletion of the rs1421085 conserved cis-regulatory module (CRM) in mice and confirmed in vivo that the CRM modulates Ir...

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Detalles Bibliográficos
Autores principales: Laber, Samantha, Forcisi, Sara, Bentley, Liz, Petzold, Julia, Moritz, Franco, Smirnov, Kirill S., Al Sadat, Loubna, Williamson, Iain, Strobel, Sophie, Agnew, Thomas, Sengupta, Shahana, Nicol, Tom, Grallert, Harald, Heier, Margit, Honecker, Julius, Mianne, Joffrey, Teboul, Lydia, Dumbell, Rebecca, Long, Helen, Simon, Michelle, Lindgren, Cecilia, Bickmore, Wendy A., Hauner, Hans, Schmitt-Kopplin, Philippe, Claussnitzer, Melina, Cox, Roger D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294759/
https://www.ncbi.nlm.nih.gov/pubmed/34290091
http://dx.doi.org/10.1126/sciadv.abg0108

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