Nuclear NAD(+) homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells

Metabolic dysregulation underlies malignant phenotypes attributed to cancer stem cells, such as unlimited proliferation and differentiation blockade. Here, we demonstrate that NAD(+) metabolism enables acute myeloid leukemia (AML) to evade apoptosis, another hallmark of cancer stem cells. We integra...

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Detalles Bibliográficos
Autores principales: Shi, Xiangguo, Jiang, Yajian, Kitano, Ayumi, Hu, Tianyuan, Murdaugh, Rebecca L., Li, Yuan, Hoegenauer, Kevin A., Chen, Rui, Takahashi, Koichi, Nakada, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294764/
https://www.ncbi.nlm.nih.gov/pubmed/34290089
http://dx.doi.org/10.1126/sciadv.abf3895

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