Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study

BACKGROUND: Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. METHODS: The thin-layer ch...

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Autores principales: Firozian, Farzin, Nili-Ahmadabadi, Amir, Moradkhani, Shirin, Moulaei, Miad, Fasihi, Zohreh, Ahmadimoghaddam, Davoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294965/
https://www.ncbi.nlm.nih.gov/pubmed/34336274
http://dx.doi.org/10.1155/2021/9968730
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author Firozian, Farzin
Nili-Ahmadabadi, Amir
Moradkhani, Shirin
Moulaei, Miad
Fasihi, Zohreh
Ahmadimoghaddam, Davoud
author_facet Firozian, Farzin
Nili-Ahmadabadi, Amir
Moradkhani, Shirin
Moulaei, Miad
Fasihi, Zohreh
Ahmadimoghaddam, Davoud
author_sort Firozian, Farzin
collection PubMed
description BACKGROUND: Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. METHODS: The thin-layer chromatography method was applied for the primary screening of potential illicit substances in the samples. The positive samples were analyzed using an isocratic high-performance liquid chromatography method. RESULTS: The results showed that 26.98% of the samples contained 17.76 ± 6.02 mg/cap of sibutramine. Daily therapeutic dose intake of sibutramine is in the range of 5 to 15 mg daily. CONCLUSION: Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers' health.
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spelling pubmed-82949652021-07-31 Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study Firozian, Farzin Nili-Ahmadabadi, Amir Moradkhani, Shirin Moulaei, Miad Fasihi, Zohreh Ahmadimoghaddam, Davoud J Obes Research Article BACKGROUND: Some anorexic agents are used to fraudulent augmentation herbal weight loss formulations. This study was designed to evaluate the potential existence of illicit substances in 63 herbal weight loss formulations collected from local apothecaries in Hamadan, Iran. METHODS: The thin-layer chromatography method was applied for the primary screening of potential illicit substances in the samples. The positive samples were analyzed using an isocratic high-performance liquid chromatography method. RESULTS: The results showed that 26.98% of the samples contained 17.76 ± 6.02 mg/cap of sibutramine. Daily therapeutic dose intake of sibutramine is in the range of 5 to 15 mg daily. CONCLUSION: Since apothecaries have advised consumers to take at least two capsules a day, it seems that the blood concentration of sibutramine will likely rise beyond the therapeutic concentration and become toxic. Therefore, the usage of such products could pose serious risks to consumers' health. Hindawi 2021-07-14 /pmc/articles/PMC8294965/ /pubmed/34336274 http://dx.doi.org/10.1155/2021/9968730 Text en Copyright © 2021 Farzin Firozian et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Firozian, Farzin
Nili-Ahmadabadi, Amir
Moradkhani, Shirin
Moulaei, Miad
Fasihi, Zohreh
Ahmadimoghaddam, Davoud
Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title_full Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title_fullStr Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title_full_unstemmed Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title_short Adulteration of the Herbal Weight Loss Products by the Illegal Addition of Synthetic Antiobesity Medications: A Pilot Study
title_sort adulteration of the herbal weight loss products by the illegal addition of synthetic antiobesity medications: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294965/
https://www.ncbi.nlm.nih.gov/pubmed/34336274
http://dx.doi.org/10.1155/2021/9968730
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