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QTc interval prolongation, inflammation, and mortality in patients with COVID-19
PURPOSE: Systemic inflammation has been associated with corrected QT (QTc) interval prolongation. The role of inflammation on QTc prolongation in COVID-19 patients was investigated. METHODS: Patients with a laboratory-confirmed SARS-CoV-2 infection admitted to IRCCS San Raffaele Scientific Institute...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295006/ https://www.ncbi.nlm.nih.gov/pubmed/34291390 http://dx.doi.org/10.1007/s10840-021-01033-8 |
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author | Gulletta, Simone Della Bella, Paolo Pannone, Luigi Falasconi, Giulio Cianfanelli, Lorenzo Altizio, Savino Cinel, Elena Da Prat, Valentina Napolano, Antonio D’Angelo, Giuseppe Brugliera, Luigia Agricola, Eustachio Landoni, Giovanni Tresoldi, Moreno Rovere, Patrizia Querini Ciceri, Fabio Zangrillo, Alberto Vergara, Pasquale |
author_facet | Gulletta, Simone Della Bella, Paolo Pannone, Luigi Falasconi, Giulio Cianfanelli, Lorenzo Altizio, Savino Cinel, Elena Da Prat, Valentina Napolano, Antonio D’Angelo, Giuseppe Brugliera, Luigia Agricola, Eustachio Landoni, Giovanni Tresoldi, Moreno Rovere, Patrizia Querini Ciceri, Fabio Zangrillo, Alberto Vergara, Pasquale |
author_sort | Gulletta, Simone |
collection | PubMed |
description | PURPOSE: Systemic inflammation has been associated with corrected QT (QTc) interval prolongation. The role of inflammation on QTc prolongation in COVID-19 patients was investigated. METHODS: Patients with a laboratory-confirmed SARS-CoV-2 infection admitted to IRCCS San Raffaele Scientific Institute (Milan, Italy) between March 14, 2020, and March 30, 2020 were included. QTc-I was defined as the QTc interval by Bazett formula in the first ECG performed during the hospitalization, before any new drug treatment; QTc-II was the QTc in the ECG performed after the initiation of hydroxychloroquine drug treatment. RESULTS: QTc-I was long in 45 patients (45%) and normal in 55 patients (55%). Patients with long QTc-I were older and more frequently males. C-Reactive protein (CRP) and white blood cell (WBC) count at hospitalization were higher in patients with long QTc-I and long QTc-II. QTc-I was significantly correlated with CRP levels at hospitalization. After a median follow-up of 83 days, 14 patients (14%) died. There were no deaths attributed to ventricular arrhythmias. Patients with long QTc-I and long QTc-II had a shorter survival, compared with normal QTc-I and QTc-II patients, respectively. In Cox multivariate analysis, independent predictors of mortality were age (HR = 1.1, CI 95% 1.04–1.18, p = 0.002) and CRP at ECG II (HR 1.1, CI 95% 1.0–1.1, p = 0.02). CONCLUSIONS: QTc at hospitalization is a simple risk marker of mortality risk in COVID-19 patients and reflects the myocardial inflammatory status. |
format | Online Article Text |
id | pubmed-8295006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-82950062021-07-22 QTc interval prolongation, inflammation, and mortality in patients with COVID-19 Gulletta, Simone Della Bella, Paolo Pannone, Luigi Falasconi, Giulio Cianfanelli, Lorenzo Altizio, Savino Cinel, Elena Da Prat, Valentina Napolano, Antonio D’Angelo, Giuseppe Brugliera, Luigia Agricola, Eustachio Landoni, Giovanni Tresoldi, Moreno Rovere, Patrizia Querini Ciceri, Fabio Zangrillo, Alberto Vergara, Pasquale J Interv Card Electrophysiol Article PURPOSE: Systemic inflammation has been associated with corrected QT (QTc) interval prolongation. The role of inflammation on QTc prolongation in COVID-19 patients was investigated. METHODS: Patients with a laboratory-confirmed SARS-CoV-2 infection admitted to IRCCS San Raffaele Scientific Institute (Milan, Italy) between March 14, 2020, and March 30, 2020 were included. QTc-I was defined as the QTc interval by Bazett formula in the first ECG performed during the hospitalization, before any new drug treatment; QTc-II was the QTc in the ECG performed after the initiation of hydroxychloroquine drug treatment. RESULTS: QTc-I was long in 45 patients (45%) and normal in 55 patients (55%). Patients with long QTc-I were older and more frequently males. C-Reactive protein (CRP) and white blood cell (WBC) count at hospitalization were higher in patients with long QTc-I and long QTc-II. QTc-I was significantly correlated with CRP levels at hospitalization. After a median follow-up of 83 days, 14 patients (14%) died. There were no deaths attributed to ventricular arrhythmias. Patients with long QTc-I and long QTc-II had a shorter survival, compared with normal QTc-I and QTc-II patients, respectively. In Cox multivariate analysis, independent predictors of mortality were age (HR = 1.1, CI 95% 1.04–1.18, p = 0.002) and CRP at ECG II (HR 1.1, CI 95% 1.0–1.1, p = 0.02). CONCLUSIONS: QTc at hospitalization is a simple risk marker of mortality risk in COVID-19 patients and reflects the myocardial inflammatory status. Springer US 2021-07-22 2022 /pmc/articles/PMC8295006/ /pubmed/34291390 http://dx.doi.org/10.1007/s10840-021-01033-8 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Gulletta, Simone Della Bella, Paolo Pannone, Luigi Falasconi, Giulio Cianfanelli, Lorenzo Altizio, Savino Cinel, Elena Da Prat, Valentina Napolano, Antonio D’Angelo, Giuseppe Brugliera, Luigia Agricola, Eustachio Landoni, Giovanni Tresoldi, Moreno Rovere, Patrizia Querini Ciceri, Fabio Zangrillo, Alberto Vergara, Pasquale QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title | QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title_full | QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title_fullStr | QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title_full_unstemmed | QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title_short | QTc interval prolongation, inflammation, and mortality in patients with COVID-19 |
title_sort | qtc interval prolongation, inflammation, and mortality in patients with covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295006/ https://www.ncbi.nlm.nih.gov/pubmed/34291390 http://dx.doi.org/10.1007/s10840-021-01033-8 |
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