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BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals

OBJECTIVE: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. METHO...

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Autores principales: Kumar, Nathella Pavan, Padmapriyadarsini, Chandrasekaran, Rajamanickam, Anuradha, Bhavani, Perumal Kannabiran, Nancy, Arul, Jeyadeepa, Bharathi, Selvaraj, Nandhini, Ashokan, Dinesh, Renji, Rachel Mariam, Venkataramani, Vijayalakshmi, Tripathy, Srikanth, Babu, Subash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295056/
https://www.ncbi.nlm.nih.gov/pubmed/34302964
http://dx.doi.org/10.1016/j.ijid.2021.07.041
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author Kumar, Nathella Pavan
Padmapriyadarsini, Chandrasekaran
Rajamanickam, Anuradha
Bhavani, Perumal Kannabiran
Nancy, Arul
Jeyadeepa, Bharathi
Selvaraj, Nandhini
Ashokan, Dinesh
Renji, Rachel Mariam
Venkataramani, Vijayalakshmi
Tripathy, Srikanth
Babu, Subash
author_facet Kumar, Nathella Pavan
Padmapriyadarsini, Chandrasekaran
Rajamanickam, Anuradha
Bhavani, Perumal Kannabiran
Nancy, Arul
Jeyadeepa, Bharathi
Selvaraj, Nandhini
Ashokan, Dinesh
Renji, Rachel Mariam
Venkataramani, Vijayalakshmi
Tripathy, Srikanth
Babu, Subash
author_sort Kumar, Nathella Pavan
collection PubMed
description OBJECTIVE: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. METHODS: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. RESULTS: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29. CONCLUSIONS: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses.
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spelling pubmed-82950562021-07-22 BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals Kumar, Nathella Pavan Padmapriyadarsini, Chandrasekaran Rajamanickam, Anuradha Bhavani, Perumal Kannabiran Nancy, Arul Jeyadeepa, Bharathi Selvaraj, Nandhini Ashokan, Dinesh Renji, Rachel Mariam Venkataramani, Vijayalakshmi Tripathy, Srikanth Babu, Subash Int J Infect Dis Article OBJECTIVE: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. METHODS: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. RESULTS: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29. CONCLUSIONS: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2021-09 2021-07-22 /pmc/articles/PMC8295056/ /pubmed/34302964 http://dx.doi.org/10.1016/j.ijid.2021.07.041 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kumar, Nathella Pavan
Padmapriyadarsini, Chandrasekaran
Rajamanickam, Anuradha
Bhavani, Perumal Kannabiran
Nancy, Arul
Jeyadeepa, Bharathi
Selvaraj, Nandhini
Ashokan, Dinesh
Renji, Rachel Mariam
Venkataramani, Vijayalakshmi
Tripathy, Srikanth
Babu, Subash
BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title_full BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title_fullStr BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title_full_unstemmed BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title_short BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals
title_sort bcg vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type i and type iii interferons in elderly individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295056/
https://www.ncbi.nlm.nih.gov/pubmed/34302964
http://dx.doi.org/10.1016/j.ijid.2021.07.041
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