Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species....

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Detalles Bibliográficos
Autores principales: Abid, Fatma Ben, Tsui, Clement K. M., Doi, Yohei, Deshmukh, Anand, McElheny, Christi L., Bachman, William C., Fowler, Erin L., Albishawi, Ahmed, Mushtaq, Kamran, Ibrahim, Emad B., Doiphode, Sanjay H., Hamed, Manal M., Almaslmani, Muna A., Alkhal, Abdullatif, Butt, Adeel A., Omrani, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295067/
https://www.ncbi.nlm.nih.gov/pubmed/33616788
http://dx.doi.org/10.1007/s10096-021-04185-7
Descripción
Sumario:One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla(NDM-1) (45; 30.2%) and bla(OXA-48) (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04185-7.

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