Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar

One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species....

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Autores principales: Abid, Fatma Ben, Tsui, Clement K. M., Doi, Yohei, Deshmukh, Anand, McElheny, Christi L., Bachman, William C., Fowler, Erin L., Albishawi, Ahmed, Mushtaq, Kamran, Ibrahim, Emad B., Doiphode, Sanjay H., Hamed, Manal M., Almaslmani, Muna A., Alkhal, Abdullatif, Butt, Adeel A., Omrani, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295067/
https://www.ncbi.nlm.nih.gov/pubmed/33616788
http://dx.doi.org/10.1007/s10096-021-04185-7
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author Abid, Fatma Ben
Tsui, Clement K. M.
Doi, Yohei
Deshmukh, Anand
McElheny, Christi L.
Bachman, William C.
Fowler, Erin L.
Albishawi, Ahmed
Mushtaq, Kamran
Ibrahim, Emad B.
Doiphode, Sanjay H.
Hamed, Manal M.
Almaslmani, Muna A.
Alkhal, Abdullatif
Butt, Adeel A.
Omrani, Ali S.
author_facet Abid, Fatma Ben
Tsui, Clement K. M.
Doi, Yohei
Deshmukh, Anand
McElheny, Christi L.
Bachman, William C.
Fowler, Erin L.
Albishawi, Ahmed
Mushtaq, Kamran
Ibrahim, Emad B.
Doiphode, Sanjay H.
Hamed, Manal M.
Almaslmani, Muna A.
Alkhal, Abdullatif
Butt, Adeel A.
Omrani, Ali S.
author_sort Abid, Fatma Ben
collection PubMed
description One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla(NDM-1) (45; 30.2%) and bla(OXA-48) (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04185-7.
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spelling pubmed-82950672021-07-23 Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar Abid, Fatma Ben Tsui, Clement K. M. Doi, Yohei Deshmukh, Anand McElheny, Christi L. Bachman, William C. Fowler, Erin L. Albishawi, Ahmed Mushtaq, Kamran Ibrahim, Emad B. Doiphode, Sanjay H. Hamed, Manal M. Almaslmani, Muna A. Alkhal, Abdullatif Butt, Adeel A. Omrani, Ali S. Eur J Clin Microbiol Infect Dis Brief Report One hundred forty-nine carbapenem-resistant Enterobacterales from clinical samples obtained between April 2014 and November 2017 were subjected to whole genome sequencing and multi-locus sequence typing. Klebsiella pneumoniae (81, 54.4%) and Escherichia coli (38, 25.5%) were the most common species. Genes encoding metallo-β-lactamases were detected in 68 (45.8%) isolates, and OXA-48-like enzymes in 60 (40.3%). bla(NDM-1) (45; 30.2%) and bla(OXA-48) (29; 19.5%) were the most frequent. KPC-encoding genes were identified in 5 (3.6%) isolates. Most common sequence types were E. coli ST410 (8; 21.1%) and ST38 (7; 18.4%), and K. pneumoniae ST147 (13; 16%) and ST231 (7; 8.6%). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04185-7. Springer Berlin Heidelberg 2021-02-22 2021 /pmc/articles/PMC8295067/ /pubmed/33616788 http://dx.doi.org/10.1007/s10096-021-04185-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Abid, Fatma Ben
Tsui, Clement K. M.
Doi, Yohei
Deshmukh, Anand
McElheny, Christi L.
Bachman, William C.
Fowler, Erin L.
Albishawi, Ahmed
Mushtaq, Kamran
Ibrahim, Emad B.
Doiphode, Sanjay H.
Hamed, Manal M.
Almaslmani, Muna A.
Alkhal, Abdullatif
Butt, Adeel A.
Omrani, Ali S.
Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title_full Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title_fullStr Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title_full_unstemmed Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title_short Molecular characterization of clinical carbapenem-resistant Enterobacterales from Qatar
title_sort molecular characterization of clinical carbapenem-resistant enterobacterales from qatar
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295067/
https://www.ncbi.nlm.nih.gov/pubmed/33616788
http://dx.doi.org/10.1007/s10096-021-04185-7
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