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The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies

PURPOSE: Peripherally acting μ-opioid receptor antagonists such as methylnaltrexone (MNTX, Relistor(®)) are indicated for the treatment of opioid-induced constipation (OIC). The structural properties unique to MNTX restrict it from traversing the blood-brain barrier (BBB); however, the BBB may becom...

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Detalles Bibliográficos
Autores principales:	Brenner, Darren M., Slatkin, Neal E., Stambler, Nancy, Israel, Robert J., Coluzzi, Paul H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295095/ https://www.ncbi.nlm.nih.gov/pubmed/33629189 http://dx.doi.org/10.1007/s00520-021-06070-7

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