Exercising under particulate matter exposure: Providing theoretical support for lung deposition and its relationship with COVID-19

The aim of the present study was to investigate lung particulate matter (PM) deposition during endurance exercise and provide a new insight concerning how SARS-CoV-2 could be carried into the respiratory tract. The anatomical and physiological characteristics of the Human Respiratory Tract model were considered for modeling the lung PM deposition during exercise. The Monte Carlo method was performed to randomly generate different values of PM concentrations (1.0, 2.5, and 10.0 μm), minute ventilation, and duration of exercise at moderate, heavy, and severe exercise intensity domains. Compared to moderate and severe intensities, during heavy exercise (75–115 L‧min-1, duration of 10.0–60.0 min) there is greater lung deposition in the bronchiolar region (p < 0.01). In turn, there is greater deposition per minute of exercise at the severe intensity domain (115.0–145.0 L‧min(−1), duration of 10.0–20.0 min, p < 0.01). Considering that SARs-CoV-2 could be adsorbed on the particles, exercising under PM exposure, mainly at the severe domain, could be harmful concerning the virus. In conclusion, beyond the traditional minute ventilation assumption, there is a time vs intensity dependence for PM deposition, whereby the severe domain presents greater deposition per minute of exercise. The results observed for PM deposition are alarming since SARs-CoV-2 could be adsorbed by particles and carried into the deeper respiratory tract.