A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer

Gut microbiota has been studied in relation to human health and disease prediction for decades. Also, immune checkpoints (ICPs) are enthusiastically investigated for anti-tumor immunotherapy. Recent studies show potential of gut microbiome and gut cytokines as biomarkers for carcinogenesis and respo...

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Autores principales: Kim, Esther, Ahn, Hyeok, Park, Hansoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295158/
https://www.ncbi.nlm.nih.gov/pubmed/33783613
http://dx.doi.org/10.1007/s00335-021-09867-3
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author Kim, Esther
Ahn, Hyeok
Park, Hansoo
author_facet Kim, Esther
Ahn, Hyeok
Park, Hansoo
author_sort Kim, Esther
collection PubMed
description Gut microbiota has been studied in relation to human health and disease prediction for decades. Also, immune checkpoints (ICPs) are enthusiastically investigated for anti-tumor immunotherapy. Recent studies show potential of gut microbiome and gut cytokines as biomarkers for carcinogenesis and response prediction of immune checkpoint inhibitor (ICI) response. Evidence has revealed that intestinal microorganisms play a major role in the effectiveness of programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade. In this review, we have focused on how microbiome and microbiome-generated cytokines affect immune checkpoints. We have also described the molecular mechanisms behind this interplay and the bacterial strains that have a potential role in immunotherapy.
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spelling pubmed-82951582021-07-23 A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer Kim, Esther Ahn, Hyeok Park, Hansoo Mamm Genome Article Gut microbiota has been studied in relation to human health and disease prediction for decades. Also, immune checkpoints (ICPs) are enthusiastically investigated for anti-tumor immunotherapy. Recent studies show potential of gut microbiome and gut cytokines as biomarkers for carcinogenesis and response prediction of immune checkpoint inhibitor (ICI) response. Evidence has revealed that intestinal microorganisms play a major role in the effectiveness of programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade. In this review, we have focused on how microbiome and microbiome-generated cytokines affect immune checkpoints. We have also described the molecular mechanisms behind this interplay and the bacterial strains that have a potential role in immunotherapy. Springer US 2021-03-30 2021 /pmc/articles/PMC8295158/ /pubmed/33783613 http://dx.doi.org/10.1007/s00335-021-09867-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Esther
Ahn, Hyeok
Park, Hansoo
A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title_full A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title_fullStr A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title_full_unstemmed A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title_short A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
title_sort review on the role of gut microbiota in immune checkpoint blockade therapy for cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295158/
https://www.ncbi.nlm.nih.gov/pubmed/33783613
http://dx.doi.org/10.1007/s00335-021-09867-3
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