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VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator of cell growth and proliferation, and hyperactivation of mTOR...
Autores principales: | Ganner, Athina, Gehrke, Christina, Klein, Marinella, Thegtmeier, Lena, Matulenski, Tanja, Wingendorf, Laura, Wang, Lu, Pilz, Felicitas, Greidl, Lars, Meid, Lisa, Kotsis, Fruzsina, Walz, Gerd, Frew, Ian J., Neumann-Haefelin, Elke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295262/ https://www.ncbi.nlm.nih.gov/pubmed/34290272 http://dx.doi.org/10.1038/s41598-021-94132-5 |
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