3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-l-kynurenamine (3-HKA) is a biogenic amine produced via an alternative pathway of tryptophan metabolism...

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Detalles Bibliográficos
Autores principales: Clement, Cristina C., D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295276/
https://www.ncbi.nlm.nih.gov/pubmed/34290243
http://dx.doi.org/10.1038/s41467-021-24785-3

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