Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays

Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seroposi...

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Autores principales: Kahre, Elisabeth, Galow, Lukas, Unrath, Manja, Haag, Luise, Blankenburg, Judith, Dalpke, Alexander H., Lück, Christian, Berner, Reinhard, Armann, Jakob P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295301/
https://www.ncbi.nlm.nih.gov/pubmed/34290329
http://dx.doi.org/10.1038/s41598-021-94453-5
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author Kahre, Elisabeth
Galow, Lukas
Unrath, Manja
Haag, Luise
Blankenburg, Judith
Dalpke, Alexander H.
Lück, Christian
Berner, Reinhard
Armann, Jakob P.
author_facet Kahre, Elisabeth
Galow, Lukas
Unrath, Manja
Haag, Luise
Blankenburg, Judith
Dalpke, Alexander H.
Lück, Christian
Berner, Reinhard
Armann, Jakob P.
author_sort Kahre, Elisabeth
collection PubMed
description Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. There are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used.
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spelling pubmed-82953012021-07-22 Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays Kahre, Elisabeth Galow, Lukas Unrath, Manja Haag, Luise Blankenburg, Judith Dalpke, Alexander H. Lück, Christian Berner, Reinhard Armann, Jakob P. Sci Rep Article Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. There are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used. Nature Publishing Group UK 2021-07-21 /pmc/articles/PMC8295301/ /pubmed/34290329 http://dx.doi.org/10.1038/s41598-021-94453-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kahre, Elisabeth
Galow, Lukas
Unrath, Manja
Haag, Luise
Blankenburg, Judith
Dalpke, Alexander H.
Lück, Christian
Berner, Reinhard
Armann, Jakob P.
Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title_full Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title_fullStr Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title_full_unstemmed Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title_short Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays
title_sort kinetics and seroprevalence of sars-cov-2 antibodies: a comparison of 3 different assays
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295301/
https://www.ncbi.nlm.nih.gov/pubmed/34290329
http://dx.doi.org/10.1038/s41598-021-94453-5
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