Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and...

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Detalles Bibliográficos
Autores principales: Levy, Joshua M., Frediani, Jennifer K., Tyburski, Erika A., Wood, Anna, Figueroa, Janet, Kempker, Russell R., Rebolledo, Paulina A., Gonzalez, Mark D., Sullivan, Julie, Vos, Miriam B., O’Neal, Jared, Martin, Greg S., Lam, Wilbur A., Waggoner, Jesse J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295385/
https://www.ncbi.nlm.nih.gov/pubmed/34290378
http://dx.doi.org/10.1038/s41598-021-94547-0
Descripción
Sumario:The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.

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