The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity

A comparative morphological study was carried out to analyze the number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 categorized by the disease severity. The number of syncytial knots was assessed on specimens stained with hematoxylin and eosin. VEGF ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Shchegolev, A. I., Kulikova, G. V., Lyapin, V. M., Shmakov, R. G., Sukhikh, G. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295457/
https://www.ncbi.nlm.nih.gov/pubmed/34292445
http://dx.doi.org/10.1007/s10517-021-05236-x
_version_ 1783725431870980096
author Shchegolev, A. I.
Kulikova, G. V.
Lyapin, V. M.
Shmakov, R. G.
Sukhikh, G. T.
author_facet Shchegolev, A. I.
Kulikova, G. V.
Lyapin, V. M.
Shmakov, R. G.
Sukhikh, G. T.
author_sort Shchegolev, A. I.
collection PubMed
description A comparative morphological study was carried out to analyze the number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 categorized by the disease severity. The number of syncytial knots was assessed on specimens stained with hematoxylin and eosin. VEGF expression was determined by immunohistochemical analysis in syncytiotrophoblast and villous endothelial cells. Morphological study of the placenta tissue of parturient women with COVID-19 showed increased numbers of syncytial knots in the villi, indicating the development of preplacental hypoxia. High VEGF expression in syncytiotrophoblast and vascular endotheliocytes reflects a stereotyped response to hypoxia and can underlie the development of a preeclampsia-like syndrome. The number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 depended on the disease severity.
format Online
Article
Text
id pubmed-8295457
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-82954572021-07-22 The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity Shchegolev, A. I. Kulikova, G. V. Lyapin, V. M. Shmakov, R. G. Sukhikh, G. T. Bull Exp Biol Med Article A comparative morphological study was carried out to analyze the number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 categorized by the disease severity. The number of syncytial knots was assessed on specimens stained with hematoxylin and eosin. VEGF expression was determined by immunohistochemical analysis in syncytiotrophoblast and villous endothelial cells. Morphological study of the placenta tissue of parturient women with COVID-19 showed increased numbers of syncytial knots in the villi, indicating the development of preplacental hypoxia. High VEGF expression in syncytiotrophoblast and vascular endotheliocytes reflects a stereotyped response to hypoxia and can underlie the development of a preeclampsia-like syndrome. The number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 depended on the disease severity. Springer US 2021-07-22 2021 /pmc/articles/PMC8295457/ /pubmed/34292445 http://dx.doi.org/10.1007/s10517-021-05236-x Text en © Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Shchegolev, A. I.
Kulikova, G. V.
Lyapin, V. M.
Shmakov, R. G.
Sukhikh, G. T.
The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title_full The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title_fullStr The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title_full_unstemmed The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title_short The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity
title_sort number of syncytial knots and vegf expression in placental villi in parturient woman with covid-19 depends on the disease severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295457/
https://www.ncbi.nlm.nih.gov/pubmed/34292445
http://dx.doi.org/10.1007/s10517-021-05236-x
work_keys_str_mv AT shchegolevai thenumberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT kulikovagv thenumberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT lyapinvm thenumberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT shmakovrg thenumberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT sukhikhgt thenumberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT shchegolevai numberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT kulikovagv numberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT lyapinvm numberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT shmakovrg numberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity
AT sukhikhgt numberofsyncytialknotsandvegfexpressioninplacentalvilliinparturientwomanwithcovid19dependsonthediseaseseverity

Ejemplares similares